MIR520H

Summary

MIR520H (microRNA 520h, HGNC:32125) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574493 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32125
Approved symbol	MIR520H
Name	microRNA 520h
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-520h
Ensembl gene	ENSG00000207861
Ensembl biotype	miRNA
OMIM	614755
Entrez	574493
RNAcentral	URS00006B6CC5 — miRNA, 88 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385126

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385126 — 1 exons

Exon	Start	End
ENSE00001500132	53742512	53742599

Expression profiles

Bgee: expression breadth broad, 11 present calls, max score 82.41.

Top tissues by expression

11 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
placenta	UBERON:0001987	82.41	gold quality
colon	UBERON:0001155	79.64	gold quality
ascending aorta	UBERON:0001496	73.11	gold quality
blood	UBERON:0000178	68.74	gold quality
esophagus mucosa	UBERON:0002469	66.68	gold quality
body of stomach	UBERON:0001161	65.88	gold quality
vagina	UBERON:0000996	64.08	gold quality
lower esophagus muscularis layer	UBERON:0035833	60.26	gold quality
testis	UBERON:0000473	56.81	gold quality
right frontal lobe	UBERON:0002810	53.64	gold quality
left testis	UBERON:0004533	40.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.15

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 16)

• Hsa-mir-519c and hsa-mir-520 directly regulate expression of the ATP-binding cassette transporter ABCG2 in human embryonic stem cells. (PMID:22887864)
• The C allele of SNP rs7201 increases a risk for endometriosis because of out of regulation by microRNA-520g. (PMID:23364396)
• Results indicate that HDAC1 is a target of miR-520h which was upregulated after doxorubicin treatment. (PMID:24316511)
• These results show that miR-520h is not only an independent prognostic factor, but is also a potential functional target for future applications in cancer therapeutics. (PMID:25982274)
• miR-520H via E2F1 could upregulate the expression levels of POLD1 and MCM2 that promotes relapse of Acute Lymphoblastic Leukemia. (PMID:29768346)
• The possible use of miR-520h as a prognostic marker for EOC. (PMID:30158641)
• NORAD affects the progression of diabetic nephropathy through targeting miR-520h to upregulate TLR4 (PMID:31630796)
• LncRNA PART1 regulates colorectal cancer via targeting miR-150-5p/miR-520h/CTNNB1 and activating Wnt/beta-catenin pathway. (PMID:31669140)
• miR-520h Stimulates Drug Resistance to Paclitaxel by Targeting the OTUD3-PTEN Axis in Breast Cancer. (PMID:32775453)
• miR-520h Inhibits cell survival by targeting mTOR in gestational diabetes mellitus. (PMID:33620957)
• Over-expression of long non-coding RNA insulin-like growth factor 2-antisense suppressed hepatocellular carcinoma cell proliferation and metastasis by regulating the microRNA-520h/cyclin-dependent kinase inhibitor 1A signaling pathway. (PMID:34516353)
• miR-146b-5p and miR-520h Expressions Are Upregulated in Serum of Women with Recurrent Spontaneous Abortion. (PMID:35083607)
• MiR-520h inhibits viability and facilitates apoptosis of KGN cells through modulating IL6R and the JAK/STAT pathway. (PMID:35085910)
• Exosomal circTAOK1 contributes to diabetic kidney disease progression through regulating SMAD3 expression by sponging miR-520h. (PMID:35142978)
• 3’UTR of SARS-CoV-2 spike gene hijack host miR-296 or miR-520h to disturb cell proliferation and cytokine signaling. (PMID:36238276)
• Circ_0091537 promotes gefitinib chemoresistance in non-small cell lung cancer by mediating the miR-520h/YAP1 network. (PMID:36727737)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.