MIR521-2

Summary

MIR521-2 (microRNA 521-2, HGNC:32113) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574481 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32113
Approved symbol	MIR521-2
Name	microRNA 521-2
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-521-2
Ensembl gene	ENSG00000207549
Ensembl biotype	miRNA
OMIM	620611
Entrez	574481
RNAcentral	URS0000670A47 — miRNA, 87 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384818

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384818 — 1 exons

Exon	Start	End
ENSE00001807590	53716594	53716680

Expression profiles

Bgee: expression breadth broad, 22 present calls, max score 77.18.

Top tissues by expression

22 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
placenta	UBERON:0001987	77.18	gold quality
heart left ventricle	UBERON:0002084	76.11	gold quality
monocyte	CL:0000576	74.08	gold quality
gastrocnemius	UBERON:0001388	74.06	gold quality
ascending aorta	UBERON:0001496	69.99	gold quality
body of pancreas	UBERON:0001150	68.86	gold quality
esophagus mucosa	UBERON:0002469	66.13	gold quality
right ovary	UBERON:0002118	63.27	gold quality
urinary bladder	UBERON:0001255	63.25	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.96	gold quality
lower esophagus muscularis layer	UBERON:0035833	62.59	gold quality
left ovary	UBERON:0002119	61.82	gold quality
spleen	UBERON:0002106	59.55	gold quality
left lobe of thyroid gland	UBERON:0001120	58.64	gold quality
tibial nerve	UBERON:0001323	58.52	gold quality
subcutaneous adipose tissue	UBERON:0002190	56.02	gold quality
skin of leg	UBERON:0001511	54.69	gold quality
right frontal lobe	UBERON:0002810	53.93	gold quality
small intestine Peyer’s patch	UBERON:0003454	46.73	gold quality
right testis	UBERON:0004534	45.74	gold quality
lung	UBERON:0002048	43.75	gold quality
left testis	UBERON:0004533	43.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.