MIR522

Summary

MIR522 (microRNA 522, HGNC:32127) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574495 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32127
Approved symbol	MIR522
Name	microRNA 522
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-522
Ensembl gene	ENSG00000283685
Ensembl biotype	miRNA
OMIM	620623
Entrez	574495
RNAcentral	URS0000680AAF — miRNA, 87 nt, 7 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385071

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385071 — 1 exons

Exon	Start	End
ENSE00001806829	53751211	53751297

Expression profiles

Bgee: expression breadth tissue_specific, 8 present calls, max score 73.11.

Top tissues by expression

8 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	73.11	gold quality
blood	UBERON:0000178	68.15	gold quality
body of pancreas	UBERON:0001150	66.70	gold quality
transverse colon	UBERON:0001157	64.49	gold quality
thoracic mammary gland	UBERON:0005200	62.86	gold quality
omental fat pad	UBERON:0010414	61.61	gold quality
lower esophagus muscularis layer	UBERON:0035833	60.56	gold quality
left testis	UBERON:0004533	46.71	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 14)

• These results suggest variation at the PLIN4 locus, and its interaction with PUFA as a modulator of obesity related phenotypes, acts in part through creation of a miR-522 regulatory site (PMID:21533135)
• miR-522 regulates cell proliferation, detachment, migration, and epithelial-mesenchymal transition. (PMID:25131211)
• Glioblastoma tumor cell proliferation was promoted through miR-522. (PMID:25776496)
• MiR522 was overexpressed in the HT29/DOX cells, the protein expression levels of ABCB5 were downregulated. (PMID:26043974)
• DKK1 (dickkopf-1) and SFRP2 (secreted frizzled-related protein 2) were the targets of miR-522 in hepatocellular carcinoma (PMID:26960688)
• The data indicate that HMGB1-miR-522-3p-PTGR1 axis may be involved in the abnormal resolution of inflammation and suggest that this mechanism might be a target for modulation of chronic inflammatory disorder. (PMID:28088550)
• Results suggested that miR-522 regulated the expression of proinflammatory cytokines and MMPs partly via targeting SOCS3 in RA synovial fibroblasts, which may contribute to pathogenesis of RA. (PMID:29394098)
• Long non-coding RNA HCG11 sponging miR-522-3p inhibits the tumorigenesis of non-small cell lung cancer by upregulating SOCS5. (PMID:32844573)
• Targeting of DeltaNp63alpha by miR-522 promotes the migration of breast epithelial cells. (PMID:33369228)
• MicroRNA-522-3p plays an oncogenic role in glioblastoma through activating Wnt/beta-catenin signaling pathway via targeting SFRP2. (PMID:33395185)
• miR-522 regulates cell proliferation, migration, invasion capacities and acts as a potential biomarker to predict prognosis in triple-negative breast cancer. (PMID:34518949)
• rs6426881 in the 3’-UTR of PBX1 is involved in breast and gastric cancers via altering the binding potential of miR-522-3p. (PMID:34655407)
• LncRNA DHRS4-AS1 ameliorates hepatocellular carcinoma by suppressing proliferation and promoting apoptosis via miR-522-3p/SOCS5 axis. (PMID:34666613)
• Long noncoding RNA LINC00238 suppresses the malignant phenotype of liver cancer by sponging miR522. (PMID:35014686)

Cross-species orthologs

0 orthologs

Paralogs (24): MIR520E (ENSG00000207599), MIR515-2 (ENSG00000207615), MIR515-1 (ENSG00000207616), MIR516A2 (ENSG00000207620), MIR526A1 (ENSG00000207629), MIR521-1 (ENSG00000207634), MIR518F (ENSG00000207706), MIR525 (ENSG00000207711), MIR520B (ENSG00000207722), MIR517A (ENSG00000207734), MIR520C (ENSG00000207738), MIR516A1 (ENSG00000207767), MIR519C (ENSG00000207788), MIR519B (ENSG00000207825), MIR517B (ENSG00000207837), MIR518B (ENSG00000207862), MIR516B1 (ENSG00000207946), MIR518E (ENSG00000207987), MIR524 (ENSG00000283289), MIR518D (ENSG00000283330), MIR523 (ENSG00000283455), MIR518C (ENSG00000283490), MIR520F (ENSG00000283540), MIR519A2 (ENSG00000284362)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.