MIR523

Summary

MIR523 (microRNA 523, HGNC:32103) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574471 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32103
Approved symbol	MIR523
Name	microRNA 523
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-523
Ensembl gene	ENSG00000283455
Ensembl biotype	miRNA
OMIM	620593
Entrez	574471
RNAcentral	URS000068F03F — miRNA, 87 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385281

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385281 — 1 exons

Exon	Start	End
ENSE00001809231	53698385	53698471

Expression profiles

Bgee: expression breadth broad, 16 present calls, max score 85.96.

Top tissues by expression

16 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
muscle of leg	UBERON:0001383	85.96	gold quality
ascending aorta	UBERON:0001496	75.19	gold quality
skin of abdomen	UBERON:0001416	72.16	gold quality
body of pancreas	UBERON:0001150	69.28	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.85	gold quality
blood	UBERON:0000178	65.97	gold quality
transverse colon	UBERON:0001157	64.98	gold quality
skin of leg	UBERON:0001511	64.85	gold quality
vagina	UBERON:0000996	63.13	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.96	gold quality
left lobe of thyroid gland	UBERON:0001120	61.57	gold quality
renal glomerulus	UBERON:0000074	60.43	gold quality
right hemisphere of cerebellum	UBERON:0014890	60.43	gold quality
tibial nerve	UBERON:0001323	59.58	gold quality
placenta	UBERON:0001987	52.77	gold quality
left testis	UBERON:0004533	42.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• LncRNA Linc-PINT inhibits miR-523-3p to hamper retinoblastoma progression by upregulating Dickkopf-1 (DKK1). (PMID:32828314)
• Long noncoding RNA LINC01638 contributes to laryngeal squamous cell cancer progression by modulating miR-523-5p/BATF3 axis. (PMID:33714208)
• LncRNA ZNF667-AS1 alleviates rheumatoid arthritis by sponging miR-523-3p and inactivating the JAK/STAT signalling pathway. (PMID:34423698)
• LncRNA ZNF667-AS1 Targets miR-523-3p/KIF5C Axis to Hinder Colon Cancer Progression. (PMID:37322260)

Cross-species orthologs

0 orthologs

Paralogs (24): MIR520E (ENSG00000207599), MIR515-2 (ENSG00000207615), MIR515-1 (ENSG00000207616), MIR516A2 (ENSG00000207620), MIR526A1 (ENSG00000207629), MIR521-1 (ENSG00000207634), MIR518F (ENSG00000207706), MIR525 (ENSG00000207711), MIR520B (ENSG00000207722), MIR517A (ENSG00000207734), MIR520C (ENSG00000207738), MIR516A1 (ENSG00000207767), MIR519C (ENSG00000207788), MIR519B (ENSG00000207825), MIR517B (ENSG00000207837), MIR518B (ENSG00000207862), MIR516B1 (ENSG00000207946), MIR518E (ENSG00000207987), MIR524 (ENSG00000283289), MIR518D (ENSG00000283330), MIR518C (ENSG00000283490), MIR520F (ENSG00000283540), MIR522 (ENSG00000283685), MIR519A2 (ENSG00000284362)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.