MIR524

Summary

MIR524 (microRNA 524, HGNC:32110) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574478 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32110
Approved symbol	MIR524
Name	microRNA 524
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-524
Ensembl gene	ENSG00000283289
Ensembl biotype	miRNA
OMIM	620599
Entrez	574478
RNAcentral	URS000063B6CA — miRNA, 87 nt, 7 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385242

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385242 — 1 exons

Exon	Start	End
ENSE00001807536	53711002	53711088

Expression profiles

Bgee: expression breadth tissue_specific, 9 present calls, max score 68.92.

Top tissues by expression

9 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibial artery	UBERON:0007610	68.92	gold quality
body of stomach	UBERON:0001161	67.70	gold quality
blood	UBERON:0000178	67.26	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.10	gold quality
vagina	UBERON:0000996	63.84	gold quality
subcutaneous adipose tissue	UBERON:0002190	62.32	gold quality
urinary bladder	UBERON:0001255	60.76	gold quality
right frontal lobe	UBERON:0002810	53.93	gold quality
left testis	UBERON:0004533	46.71	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.15

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 23)

• Loss of miR-524-5p is associated with glioma. (PMID:22871495)
• The findings provide new insight into the role of miR-524-5p as an important miRNA that negatively regulates the MAPK/ERK signaling pathway, suggesting that miR-524-5p could be a potent therapeutic candidate for melanoma treatment. (PMID:25275294)
• we identified SOX9 as a functional target protein of miR-524-5p and found that SOX9 overexpression could counteracts the chemosensitizing effects of miR-524-5p. (PMID:27880941)
• These findings suggest that miR-524-5p appears to play a critical role in the regulation of biological properties of PDFS cells, and may represent a potential therapeutic target for nonfunctional pituitary adenomas. (PMID:28472828)
• EGFR amplification/EGFRvIII mutation can repress the expression of Pri-miR-524 by histone modification. MiR-524-3p and miR-524-5p inhibited TGF/beta, Notch and the Hippo pathway by targeting Smad2, Hes1 and Tead1, respectively; these pathways repressed their common downstream transcription factor, C-myc. (PMID:28778566)
• miR-524-5p targets TP53IPN1, ZEB2, SMAD4 and promotes mesenchymal-to-epithelial transition. (PMID:28962647)
• MiR-524-5p targeting on FOXE1 and ITGA3 prevents thyroid cancer progression through different pathways including cell cycling and autophagy. (PMID:30941771)
• TUG1 participated in the development of OSCC as a competing endogenous RNA to competitively bind to miR-524-5p and thus mediate DLX1 expression. (PMID:30980391)
• MicroRNA-524-5p suppresses cell proliferation and promotes cell apoptosis in gastric cancer by regulating CASP3. (PMID:31599422)
• Downregulated miR-524-5p Participates in the Tumor Microenvironment of Ameloblastoma by Targeting the Interleukin-33 (IL-33)/Suppression of Tumorigenicity 2 (ST2) Axis. (PMID:31990904)
• These results indicated that miRNA-524-5p inhibited angiogenesis in colon cancer cells via targeting WNK1. (PMID:32174132)
• MiR-524-5p Suppresses Migration, Invasion, and EMT Progression in Breast Cancer Cells Through Targeting FSTL1. (PMID:32298609)
• microRNA-524-5p inhibits proliferation and induces cell cycle arrest of osteosarcoma cells via targeting CDK6. (PMID:32747087)
• miR-524-5p reduces the progression of the BRAF inhibitor-resistant melanoma. (PMID:33142243)
• MiR-524 suppressed the progression of oral squamous cell carcinoma by suppressing Metadherin and NF-kappaB signaling pathway in OSCC cell lines. (PMID:33676362)
• MicroRNA5245p regulates the proliferation and invasion of HTR8/SVneo trophoblasts by targeting NUMB in the Notch signaling pathway. (PMID:33846809)
• Long noncoding RNA SChLAP1 regulates the proliferation of triple negative breast cancer cells via the miR5245p/HMGA2 axis. (PMID:33846810)
• Down-regulation of circITCH promotes osteosarcoma development and resistance to doxorubicin via the miR-524/RASSF6 axis. (PMID:34151476)
• LINC00184 plays an oncogenic role in non-small cell lung cancer via regulation of the miR-524-5p/HMGB2 axis. (PMID:34651416)
• Long noncoding RNA NEAT1 inhibits the acetylation of PTEN through the miR-524-5p /HDAC1 axis to promote the proliferation and invasion of laryngeal cancer cells. (PMID:34837887)
• YAP/miR-524-5p axis negatively regulates TXNIP expression to promote chondrosarcoma cell growth. (PMID:34968780)
• Long non-coding RNA nuclear enriched abundant transcript 1 (NEAT1) modulates inhibitor of DNA binding 1 (ID1) to facilitate papillary thyroid carcinoma development by sponging microRNA-524-5p. (PMID:35635748)
• Integrative Bioinformatics Analysis Reveals That miR-524-5p/MEF2C Regulates Bone Metastasis in Prostate Cancer and Breast Cancer. (PMID:36128051)

Cross-species orthologs

0 orthologs

Paralogs (24): MIR520E (ENSG00000207599), MIR515-2 (ENSG00000207615), MIR515-1 (ENSG00000207616), MIR516A2 (ENSG00000207620), MIR526A1 (ENSG00000207629), MIR521-1 (ENSG00000207634), MIR518F (ENSG00000207706), MIR525 (ENSG00000207711), MIR520B (ENSG00000207722), MIR517A (ENSG00000207734), MIR520C (ENSG00000207738), MIR516A1 (ENSG00000207767), MIR519C (ENSG00000207788), MIR519B (ENSG00000207825), MIR517B (ENSG00000207837), MIR518B (ENSG00000207862), MIR516B1 (ENSG00000207946), MIR518E (ENSG00000207987), MIR518D (ENSG00000283330), MIR523 (ENSG00000283455), MIR518C (ENSG00000283490), MIR520F (ENSG00000283540), MIR522 (ENSG00000283685), MIR519A2 (ENSG00000284362)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.