MIR525

Summary

MIR525 (microRNA 525, HGNC:32102) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574470 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32102
Approved symbol	MIR525
Name	microRNA 525
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-525
Ensembl gene	ENSG00000207711
Ensembl biotype	miRNA
OMIM	620592
Entrez	574470
RNAcentral	URS000075E848 — miRNA, 85 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384978

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384978 — 1 exons

Exon	Start	End
ENSE00001806946	53697533	53697617

Expression profiles

Bgee: expression breadth tissue_specific, 7 present calls, max score 77.57.

Top tissues by expression

7 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
placenta	UBERON:0001987	77.57	gold quality
omental fat pad	UBERON:0010414	74.24	gold quality
blood	UBERON:0000178	67.43	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.74	gold quality
minor salivary gland	UBERON:0001830	63.20	gold quality
skin of abdomen	UBERON:0001416	61.64	gold quality
left testis	UBERON:0004533	49.47	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.41

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 19)

• The transient up-regulation of miR-525-3p, and the resultant repression of its direct targets ARRB1, TXN1 and HSPA9, is required for cell survival following irradiation. (PMID:24147004)
• miR-525-3p promotes liver cancer cell migration and invasion by directly targeting ZNF395. (PMID:24599008)
• miRNA-516a-3p, miRNA-629 and miRNA-525-5p are expressed in pediatric SLE patients with active disease (PMID:24687380)
• miRNA 525-5p, shown to target the 3’UTR of VPAC-1, is more efficient in decreasing GFP expression when co-expressed with constructs carrying the allele C at rs896 suggesting this miRNA regulates VPAC-1 expression differently depending on polymorphism (PMID:25390694)
• Authors confirmed that miR-525-3p was complementary to the 3’ untranslated region (UTR) of nonstructural protein 1(NSP1) of RV (Wa or Rhesus) strains. Interestingly, miR-525-3p induced type I interferon (IFN) expression and proinflammatory cytokines during RV infection through IFN regulatory factor (IRF) 3/IRF7 and NF-kappaB activation, which can induce an antiviral state to further suppress RV infection. (PMID:28890396)
• The elevated expression of SEMG1 and reduced expression of miR-525-3p are associated with AZS and male infertility (PMID:30575326)
• MiR-525-5p Repressed Metastasis and Anoikis Resistance in Cervical Cancer via Blocking UBE2C/ZEB1/2 Signal Axis. (PMID:31679088)
• Androgen receptor suppresses prostate cancer metastasis but promotes bladder cancer metastasis via differentially altering miRNA525-5p/SLPI-mediated vasculogenic mimicry formation. (PMID:31843555)
• ADPGK-AS1 promotes the progression of colorectal cancer via sponging miR-525 to upregulate FUT1. (PMID:32196589)
• Role of lncRNAHCP5/microRNA-525-5p/PRC1 crosstalk in the malignant behaviors of ovarian cancer cells. (PMID:32511950)
• Regulatory mechanism of miR-525-5p in over-invasion of trophoblast. (PMID:33258220)
• Circular RNA_0074027 participates in cell proliferation, apoptosis and metastasis of colorectal cancer cells through regulation of miR5253p. (PMID:33760126)
• Circular RNA FAT atypical cadherin 1 (circFAT1)/microRNA-525-5p/spindle and kinetochore-associated complex subunit 1 (SKA1) axis regulates oxaliplatin resistance in breast cancer by activating the notch and Wnt signaling pathway. (PMID:34288822)
• Hsa_circ_0001361 facilitates the progress of lung adenocarcinoma cells via targeting miR-525-5p/VMA21 axis. (PMID:34507559)
• Hsa_circ_0088196 suppresses trophoblast migration and invasion by the miR-525-5p/ABL1 axis and the PI3K/AKT signaling pathway. (PMID:35781906)
• By modulating miR-525-5p/Bax axis, LINC00659 promotes vascular endothelial cell apoptosis. (PMID:36705418)
• LINC00313 promotes the proliferation and inhibits the apoptosis of chondrocytes via regulating miR-525-5p/GDF5 axis. (PMID:36823651)
• Long Non-coding RNA ZFAS1 Regulates Fibrosis and Scortosis in the Cell Model of Diabetic Nephropathy Through miR-525-5p/SGK1 Axis. (PMID:37768477)
• MiR-525-5p inhibits diffuse large B cell lymphoma progression via the Myd88/NF-kappaB signaling pathway. (PMID:37953776)

Cross-species orthologs

0 orthologs

Paralogs (24): MIR520E (ENSG00000207599), MIR515-2 (ENSG00000207615), MIR515-1 (ENSG00000207616), MIR516A2 (ENSG00000207620), MIR526A1 (ENSG00000207629), MIR521-1 (ENSG00000207634), MIR518F (ENSG00000207706), MIR520B (ENSG00000207722), MIR517A (ENSG00000207734), MIR520C (ENSG00000207738), MIR516A1 (ENSG00000207767), MIR519C (ENSG00000207788), MIR519B (ENSG00000207825), MIR517B (ENSG00000207837), MIR518B (ENSG00000207862), MIR516B1 (ENSG00000207946), MIR518E (ENSG00000207987), MIR524 (ENSG00000283289), MIR518D (ENSG00000283330), MIR523 (ENSG00000283455), MIR518C (ENSG00000283490), MIR520F (ENSG00000283540), MIR522 (ENSG00000283685), MIR519A2 (ENSG00000284362)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.