MIR526A2

Summary

MIR526A2 (microRNA 526a-2, HGNC:32118) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574486 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32118
Approved symbol	MIR526A2
Name	microRNA 526a-2
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-526a-2
Ensembl gene	ENSG00000211532
Ensembl biotype	miRNA
OMIM	620615
Entrez	574486
RNAcentral	URS000075D745 — miRNA, 65 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390198

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390198 — 1 exons

Exon	Start	End
ENSE00001507625	53726922	53726986

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 74.85.

Top tissues by expression

4 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	74.85	gold quality
right lobe of liver	UBERON:0001114	68.34	gold quality
lower esophagus muscularis layer	UBERON:0035833	62.52	gold quality
tibial nerve	UBERON:0001323	58.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Results provide evidence for stimulatory role of miR-526a in tumor migration and invasion through modulation of the canonical NF-kappaB signaling pathway. (PMID:26002288)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.