MIR526B

Summary

MIR526B (microRNA 526b, HGNC:32100) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574468 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32100
Approved symbol	MIR526B
Name	microRNA 526b
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-526b
Ensembl gene	ENSG00000207580
Ensembl biotype	miRNA
OMIM	620589
Entrez	574468
RNAcentral	URS000075D282 — miRNA, 83 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384848

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384848 — 1 exons

Exon	Start	End
ENSE00001806903	53694393	53694475

Expression profiles

Bgee: expression breadth broad, 14 present calls, max score 73.53.

Top tissues by expression

14 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus muscularis layer	UBERON:0035833	73.53	gold quality
left adrenal gland cortex	UBERON:0035825	71.02	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.68	gold quality
renal glomerulus	UBERON:0000074	68.58	gold quality
vagina	UBERON:0000996	66.15	gold quality
blood	UBERON:0000178	65.82	gold quality
tibial artery	UBERON:0007610	65.66	gold quality
esophagus mucosa	UBERON:0002469	65.18	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.27	gold quality
right lobe of liver	UBERON:0001114	61.19	gold quality
spleen	UBERON:0002106	60.58	gold quality
placenta	UBERON:0001987	55.05	gold quality
testis	UBERON:0000473	45.99	gold quality
left testis	UBERON:0004533	45.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 23)

• A robust association is established between the rs8506G>A polymorphism in the lincRNA-NR_024015 exon and the risk of non-cardia gastric cancer. (PMID:24595048)
• Ku80 restoration partially reversed cell cycle arrest and apoptosis induced by hsa-miR-526b in NSCLC cells in vitro and in vivo. In addition, hsa-miR-526b overexpression or Ku80 knockdown increased p53 and p21CIP1/WAF1 expression. (PMID:25596743)
• miRNA 526b is a COX-2 upregulated, oncogenic miRNA promoting stem-like cells, the expression of which follows EP4 receptor-mediated signaling. (PMID:25733698)
• miR-526b, an miRNA belonging to C19MC, can target the 377-383 region of the MMP1 3’ Untranslated Region. (PMID:26292968)
• miR-526b was decreased in CC cells and CC clinical specimens, especially in CC specimens with stromal invasion, pelvic lymph node metastasis and deficiency vaginal involvement. Moreover, it was proved that the character of miR-526b in CC was dependent on controlling the PBX3-mediated EMT process. (PMID:30859853)
• miR-526b inhibits KDM4A expression to regulate the growth and invasion of gastric cancer cells. (PMID:31349968)
• This study establishes the dynamic functions of miR526b/miR655 in oxidative stress induction in breast cancer. (PMID:31430859)
• MiR-526b-3p mediates doxorubicin-induced cardiotoxicity by targeting STAT3 to inactivate VEGFA. (PMID:31958751)
• Oncogenic hsa_circ_0091581 promotes the malignancy of HCC cell through blocking miR-526b from degrading c-MYC mRNA. (PMID:32116112)
• Circular RNA PVT1 promotes metastasis via regulating of miR-526b/FOXC2 signals in OS cells. (PMID:32249539)
• MiR-526b suppresses cell proliferation, cell invasion and epithelial-mesenchymal transition in breast cancer by targeting Twist1. (PMID:32271429)
• ATG7 promotes autophagy in sepsisinduced acute kidney injury and is inhibited by miR526b. (PMID:32323768)
• Long Noncoding RNA HOXD-AS1 Promotes the Proliferation, Migration, and Invasion of Colorectal Cancer via the miR-526b-3p/CCND1 Axis. (PMID:32640404)
• LncRNA LINC00689 Promotes the Tumorigenesis of Glioma via Mediation of miR-526b-3p/IGF2BP1 Axis. (PMID:33389570)
• Long non-coding RNA HOTAIR promotes hepatocellular carcinoma progression by regulating miR-526b-3p/DHX33 axis. (PMID:33843021)
• miR-526b-3p inhibits lung cancer cisplatin-resistance and metastasis by inhibiting STAT3-promoted PD-L1. (PMID:34321456)
• The miR526b-5p-Related Single Nucleotide Polymorphisms, rs72618599, Located in 3’-UTR of TCF3 Gene, is Associated with the Risk of Breast and Gastric Cancers (PMID:34700372)
• LncRNA LOXL1-AS1 Facilitates the Oncogenic Character in Cervical Cancer by the miR-526b-5p /LYPLA1 Axis. (PMID:34984578)
• Serum-derived extracellular vesicles facilitate temozolomide resistance in glioblastoma through a HOTAIR-dependent mechanism. (PMID:35418162)
• MiR-526b targets lncRNA SLC16A1-AS1 to suppress cell proliferation in triple-negative breast cancer. (PMID:36654514)
• miR-526b-5p/c-Myc/Foxp1 participates in recurrent spontaneous abortion by regulating the proliferation, migration, and invasion of trophoblasts. (PMID:37052757)
• MiR-526b-3p enhances sensitivity of head and neck squamous cell carcinoma cells to radiotherapy via suppressing exosomal LAMP3-mediated autophagy. (PMID:37740656)
• LINC01343 targets miR-526b-5p to facilitate the development of hepatocellular carcinoma by upregulating ROBO1. (PMID:37828032)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.