MIR527

Summary

MIR527 (microRNA 527, HGNC:32129) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574497 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32129
Approved symbol	MIR527
Name	microRNA 527
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-527
Ensembl gene	ENSG00000207979
Ensembl biotype	miRNA
OMIM	620625
Entrez	574497
RNAcentral	URS00006512AF — miRNA, 85 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385244

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385244 — 1 exons

Exon	Start	End
ENSE00001809044	53754018	53754102

Expression profiles

Bgee: expression breadth broad, 21 present calls, max score 73.40.

Top tissues by expression

21 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	73.40	gold quality
monocyte	CL:0000576	72.36	gold quality
right adrenal gland	UBERON:0001233	71.45	gold quality
blood	UBERON:0000178	71.17	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.66	gold quality
caudate nucleus	UBERON:0001873	69.20	gold quality
ascending aorta	UBERON:0001496	67.41	gold quality
transverse colon	UBERON:0001157	66.54	gold quality
right lobe of liver	UBERON:0001114	66.31	gold quality
body of stomach	UBERON:0001161	66.31	gold quality
omental fat pad	UBERON:0010414	65.88	gold quality
fundus of stomach	UBERON:0001160	65.49	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.07	gold quality
thoracic mammary gland	UBERON:0005200	65.03	gold quality
esophagus mucosa	UBERON:0002469	64.92	gold quality
adult mammalian kidney	UBERON:0000082	64.67	gold quality
vagina	UBERON:0000996	63.96	gold quality
spleen	UBERON:0002106	61.28	gold quality
ectocervix	UBERON:0012249	61.15	gold quality
small intestine Peyer’s patch	UBERON:0003454	53.70	gold quality
left testis	UBERON:0004533	44.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• Mir527 overexpression is associated with metastasis in osteosarcoma. (PMID:26988989)
• This study found a novel signaling pathway, namely MNX1-AS1/miR-527/BRF2 axis, involved in lung cancer progression. (PMID:30618167)
• miR-527 targeting SULF2 down-regulates SULF2 expression, concurrently, suppresses NSCLC epithelial-mesenchymal transition and invasion via inhibiting TGF-beta/SMAD signaling pathway in non-small-cell lung cancer (PMID:31499680)
• circRNA_0005529 facilitates growth and metastasis of gastric cancer via regulating miR-527/Sp1 axis. (PMID:33472586)
• Circular RNA_0001495 increases Robo1 expression by sponging microRNA-527 to promote the proliferation, migration and invasion of bladder cancer cells. (PMID:34021307)
• hsa_circ_0003222 accelerates stemness and progression of non-small cell lung cancer by sponging miR-527. (PMID:34433810)
• Inhibition of circular RNA circ_0138959 alleviates pyroptosis of human gingival fibroblasts via the microRNA-527/caspase-5 axis. (PMID:35030963)
• Potential plasma microRNAs signature miR-190b-5p, miR-215-5p and miR-527 as non-invasive biomarkers for prostate cancer. (PMID:36644827)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.