MIR532

Summary

MIR532 (microRNA 532, HGNC:32795) is a microRNA gene on chromosome Xp11.23.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693124 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32795
Approved symbol	MIR532
Name	microRNA 532
Location	Xp11.23
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-532
Ensembl gene	ENSG00000207758
Ensembl biotype	miRNA
OMIM	301023
Entrez	693124
RNAcentral	URS00007B250F — miRNA, 91 nt, 8 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385025

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385025 — 1 exons

Exon	Start	End
ENSE00001500032	50003148	50003238

Expression profiles

Bgee: expression breadth broad, 18 present calls, max score 82.77.

Top tissues by expression

18 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.77	gold quality
kidney	UBERON:0002113	82.37	gold quality
lung	UBERON:0002048	81.59	gold quality
adrenal tissue	UBERON:0018303	81.29	gold quality
blood	UBERON:0000178	80.87	gold quality
colon	UBERON:0001155	73.47	gold quality
multicellular organism	UBERON:0000468	70.38	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.21	gold quality
stomach	UBERON:0000945	68.55	gold quality
body of pancreas	UBERON:0001150	68.43	gold quality
endometrium	UBERON:0001295	67.65	gold quality
skin of abdomen	UBERON:0001416	66.80	gold quality
body of stomach	UBERON:0001161	65.98	gold quality
skin of leg	UBERON:0001511	64.07	gold quality
right frontal lobe	UBERON:0002810	62.71	gold quality
left ovary	UBERON:0002119	61.70	gold quality
tibial nerve	UBERON:0001323	59.28	gold quality
cerebellar hemisphere	UBERON:0002245	58.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• Up-regulation of mir-532 is associated with melanoma progression. (PMID:19336521)
• Lower expression of miR-532-5p was significantly associated with overexpression of Her-2/neu and thus ovarian neoplasms (PMID:22925189)
• Low MIRN532 expression is associated with chronic lymphocytic leukemia. (PMID:24916701)
• Concentration of serum MIR532 were altered in Deep vein thrombosis subjects. Statistical analysis showed a profile of serum MIR532 that might be useful as a biomarker for DVT detection after major orthopedic surgery. (PMID:25244974)
• Results show that differential methylation between sexes is associated with altered levels of microRNAs miR-660 and miR-532 and related target genes. (PMID:25517766)
• miR-532-5p functions as an oncogenic miRNA by promoting cell growth, migration and invasion in human gastric cancer cells via regulation of RUNX3 gene expression. (PMID:26515139)
• Upregulation of miR-532-5p and subsequent suppression of the SESTD1 and TAB3 genes represent an antiviral response aimed at limiting West Nile virus infection. (PMID:26676784)
• we have discovered that miR-532-5p acts as a significant tumor-suppressor in ovarian cancer and that miR-532-5p expression is connected to ovarian cancer patient survival outcomes. (PMID:26873729)
• Low miR532 expression is associated with lung adenocarcinoma. (PMID:27036025)
• The quantitative trait loci analysis revealed a significant gender effect of the FoxP3 promoter polymorphism rs3761548A/C on miR-221, miR-222 and miR-532 expression levels, and of the FoxP3 polymorphism rs2232365A/G on miR-221 expression levels in peripheral leukocytes of rheumatoid arthritis patients. (PMID:27834806)
• miR-125b and miR-532-3p are potential non-invasive biomarkers, detectable in the peripheral blood of CLL patients before treatment, which predict rituximab-mediated lymphodepletion efficacy. (PMID:28126961)
• findings demonstrate a miR-532/miR-3064-mediated mechanism responsible for hTERT upregulation in OC cells, and reveal a possibility of targeting miR-532/miR-3064 for future treatment of OC (PMID:28291810)
• we found miR-532 was upregulated in gastric cancer cells and tissues, and promoted gastric cancer cell migration and invasion by targeting NKD1. (PMID:28356225)
• our findings show that miR-532-5p is a novel transcriptional target of TTF-1 that plays a tumor suppressive role by targeting KRAS and MKL2 in lung adenocarcinoma (PMID:28474808)
• Hsa_circRNA_103809 participates in the regulation of biological functions through the miR-532-3P/FOXO4 axis in the colorectal cancer (PMID:30249393)
• data suggested that miR-532-5p may act as a novel prognostic marker in epithelial ovarian cancer. (PMID:30280764)
• We found that miR-532 was significantly upregulated in patients with intervertebral disc degeneration and plays a pro-apoptotic role in human intervertebral disc nucleus pulposus cells. Further, Bcl-9 was confirmed to be a direct target of miR-532 and might be a potential target for disc degeneration therapy. (PMID:30472057)
• MIR-532 is up-regulated in hepatocellular carcinoma and contributes to hepatocellular carcinoma cell mobility and proliferation through targeting PTPRT. (PMID:30551553)
• MiR-532-5p inhibited the proliferation and invasion of bladder cancer cells by targeting HMGB3 and downregulating Wnt/beta-catenin signaling, suggesting a tumor suppressive role of miR-532-5p in bladder cancer. (PMID:30639441)
• Long non-coding RNA DARS-AS1 promotes tumorigenesis of non-small cell lung cancer via targeting miR-532-3p. (PMID:31317683)
• miR-532 promotes cell proliferation and invasion in t(4;14) MMs by targeting CAMK2N1 (PMID:31452083)
• miR-532 is highly expressed in colorectal cancer cells and directly inhibits NKD1 expression (PMID:31472047)
• MiR-188-3p, miR-501-3p, miR-502-3p, miR-532-3p and miR-532-5p in serum were also observed to be up-regulated in breast cancer patients. (PMID:31493506)
• MiR-532-3p suppresses colorectal cancer progression by disrupting the ETS1/TGM2 axis-mediated Wnt/beta-catenin signaling. (PMID:31570702)
• Circular RNA Sequencing Identifies CircASAP1 as a Key Regulator in Hepatocellular Carcinoma Metastasis. (PMID:31838741)
• The expression level of miR-532-3p were detected in NSCLC tissues and cells by qRT-PCR, which indicated that the expression of miR-532-3p was low in both tissue and cell levels. (PMID:31983096)
• Plasma exosome-derived microRNA-532 as a novel predictor for acute myeloid leukemia. (PMID:32176633)
• Inflammation-dependent downregulation of miR-532-3p mediates apoptotic signaling in human sarcopenia through targeting BAK1. (PMID:32226296)
• MiR-532-5p Suppresses Migration and Invasion of Lung Cancer Cells Through Inhibiting CCR4. (PMID:32228308)
• MicroRNA-532-5p is implicated in the regulation of osteoporosis by forkhead box O1 and osteoblast differentiation. (PMID:32404197)
• Circular RNA circMDM2 accelerates the glycolysis of oral squamous cell carcinoma by targeting miR-532-3p/HK2. (PMID:32410389)
• Upregulation of microRNA-532 enhances cardiomyocyte apoptosis in the diabetic heart. (PMID:32418060)
• Serum Exosomal miRNAs for Grading Hepatic Fibrosis Due to Schistosomiasis. (PMID:32443549)
• miR-532-3p-CSF2RA Axis as a Key Regulator of Vulnerable Atherosclerotic Plaque Formation. (PMID:32473103)
• Circular RNA circFGD4 suppresses gastric cancer progression via modulating miR-532-3p/APC/beta-catenin signalling pathway. (PMID:32633323)
• MicroRNA-532-5p is a prognostic marker and inhibits the aggressive phenotypes of osteosarcoma through targeting CXCL2. (PMID:32643867)
• MicroRNA Expression Profiling of Epithelial Ovarian Cancer Identifies New Markers of Tumor Subtype. (PMID:32703147)
• Low expression of miR5323p contributes to cerebral ischemia/reperfusion oxidative stress injury by directly targeting NOX2. (PMID:32705253)
• MicroRNA-532-3p Regulates Pro-Inflammatory Human THP-1 Macrophages by Targeting ASK1/p38 MAPK Pathway. (PMID:32876895)
• miR-532-3p: a possible altered miRNA in cumulus cells of infertile women with advanced endometriosis. (PMID:33358886)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir532	ENSMUSG00000070139
rattus_norvegicus	Mir532	ENSRNOG00000036245

Paralogs (2): MIR188 (ENSG00000207768), MIR660 (ENSG00000207970)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.