MIR541

Summary

MIR541 (microRNA 541, HGNC:33650) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126308 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33650
Approved symbol	MIR541
Name	microRNA 541
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-541
Ensembl gene	ENSG00000216179
Ensembl biotype	miRNA
Entrez	100126308
RNAcentral	URS000075BC5F — miRNA, 84 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401360

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401360 — 1 exons

Exon	Start	End
ENSE00001546704	101064495	101064578

Expression profiles

Bgee: expression breadth broad, 81 present calls, max score 97.36.

Top tissues by expression

81 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	97.36	gold quality
placenta	UBERON:0001987	86.40	gold quality
muscle of leg	UBERON:0001383	80.48	gold quality
left ovary	UBERON:0002119	78.42	gold quality
adrenal gland	UBERON:0002369	77.70	gold quality
vagina	UBERON:0000996	77.41	gold quality
left adrenal gland cortex	UBERON:0035825	77.03	gold quality
gastrocnemius	UBERON:0001388	76.68	gold quality
left adrenal gland	UBERON:0001234	75.91	gold quality
ovary	UBERON:0000992	75.86	gold quality
right atrium auricular region	UBERON:0006631	75.64	gold quality
body of pancreas	UBERON:0001150	75.63	gold quality
pancreas	UBERON:0001264	75.36	gold quality
lung	UBERON:0002048	75.35	gold quality
prefrontal cortex	UBERON:0000451	75.30	gold quality
right adrenal gland cortex	UBERON:0035827	74.98	gold quality
stomach	UBERON:0000945	74.73	gold quality
heart	UBERON:0000948	74.58	gold quality
right adrenal gland	UBERON:0001233	73.83	gold quality
adult mammalian kidney	UBERON:0000082	73.66	gold quality
heart left ventricle	UBERON:0002084	73.22	gold quality
body of uterus	UBERON:0009853	72.67	gold quality
endometrium	UBERON:0001295	72.55	gold quality
gall bladder	UBERON:0002110	72.28	gold quality
body of stomach	UBERON:0001161	71.08	gold quality
omental fat pad	UBERON:0010414	70.68	gold quality
myometrium	UBERON:0001296	70.56	gold quality
adipose tissue	UBERON:0001013	70.41	gold quality
islet of Langerhans	UBERON:0000006	70.09	gold quality
kidney	UBERON:0002113	69.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 17)

• Significant expression differences in miR-541 were detected between individuals who died at daytime and nighttime. (PMID:23254460)
• Observations indicate stage-specific roles of OstemiR especially miR-541 and the miR-30 family on novel targets in osteogenesis. (PMID:23533592)
• these results concluded that infiltrating CD4(+) T cells could promote PCa metastasis via modulation of FGF11–>miRNA-541–>AR–>MMP9 signaling. (PMID:25135278)
• Data show that TGFB-induced factor 2 protein (TGIF2) is involved in microRNA miR-541-3p-regulated cell proliferation, invasion, migration, as well as cell cycle of non-small lung cancer (NSCLC) cells. (PMID:27448300)
• our study revealed that miR-541 inhibited SCLC proliferation and invasion by directly targeting HMGA2. (PMID:29659195)
• LOXL1-AS1 regulates prostate cancer cell proliferation and cell cycle progression through miR-541-3p and CCND1. (PMID:30278884)
• Low miR-541 expression is associated with progression of intrahepatic cholangiocarcinoma. (PMID:31590696)
• Role of miR-541-3p/TMPRSS4 in the metastasis and EMT of hepatocellular carcinoma. (PMID:31858539)
• Downregulation of miR-541 induced by heat stress contributes to malignant transformation of human bronchial epithelial cells via HSP27. (PMID:32145546)
• miR-541 serves as a prognostic biomarker of osteosarcoma and its regulatory effect on tumor cell proliferation, migration and invasion by targeting TGIF2. (PMID:32709240)
• Long non-coding RNA NORAD promotes the prostate cancer cell extracellular vesicle release via microRNA-541-3p-regulated PKM2 to induce bone metastasis of prostate cancer. (PMID:33722248)
• miR5413p inhibits the viability and migration of vascular smooth muscle cells via targeting STIM1. (PMID:33760103)
• CircRTN4IP1 regulates the malignant progression of intrahepatic cholangiocarcinoma by sponging miR-541-5p to induce HIF1A production. (PMID:34974242)
• MicroRNA-541-5p REgulates Type II Alveolar Epithelial Cell Proliferation and Activity by Modulating the HMGB1 Expression. (PMID:35271544)
• Circ_0085616 contributes to the radio-resistance and progression of cervical cancer by targeting miR-541-3p/ARL2 signaling. (PMID:36300495)
• miR-541 is associated with the prognosis of liver cirrhosis and directly targets JAG2 to inhibit the activation of hepatic stellate cells. (PMID:38395762)
• Gastric cancer cell-derived exosomal miR-541-5p induces M2 macrophage polarization through DUSP3/JAK2/STAT3 pathway. (PMID:39103776)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir541	ENSMUSG00000076052
rattus_norvegicus	Mir541	ENSRNOG00000036486

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.