MIR544A

Summary

MIR544A (microRNA 544a, HGNC:32530) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 664613 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32530
Approved symbol	MIR544A
Name	microRNA 544a
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-544
Ensembl gene	ENSG00000207587
Ensembl biotype	miRNA
Entrez	664613
RNAcentral	URS0000674174 — miRNA, 91 nt, 26 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384855

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384855 — 1 exons

Exon	Start	End
ENSE00001499862	101048658	101048748

Expression profiles

Bgee: expression breadth broad, 68 present calls, max score 98.00.

Top tissues by expression

68 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	98.00	gold quality
stomach	UBERON:0000945	86.79	gold quality
placenta	UBERON:0001987	79.81	gold quality
kidney	UBERON:0002113	78.46	gold quality
blood	UBERON:0000178	76.14	gold quality
monocyte	CL:0000576	75.39	gold quality
gastrocnemius	UBERON:0001388	75.00	gold quality
lung	UBERON:0002048	74.35	gold quality
adult mammalian kidney	UBERON:0000082	74.15	gold quality
intestine	UBERON:0000160	73.97	gold quality
endometrium	UBERON:0001295	73.01	gold quality
right atrium auricular region	UBERON:0006631	72.56	gold quality
heart	UBERON:0000948	72.09	gold quality
body of pancreas	UBERON:0001150	71.62	gold quality
colon	UBERON:0001155	70.65	gold quality
heart left ventricle	UBERON:0002084	70.58	gold quality
liver	UBERON:0002107	70.29	gold quality
left ovary	UBERON:0002119	69.55	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.34	gold quality
amygdala	UBERON:0001876	69.26	gold quality
right frontal lobe	UBERON:0002810	68.96	gold quality
left adrenal gland cortex	UBERON:0035825	68.65	gold quality
substantia nigra	UBERON:0002038	68.61	gold quality
left adrenal gland	UBERON:0001234	68.57	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.29	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.77	gold quality
ovary	UBERON:0000992	67.59	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.36	gold quality
right adrenal gland	UBERON:0001233	67.11	gold quality
Ammon’s horn	UBERON:0001954	67.04	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 17)

• The miR-544 may be a potential molecular target in miRNA-based strategy on gastric cancer. (PMID:22934698)
• miR-544a may activate the WNT signaling pathway through the stabilization of beta-catenin in nucleus. (PMID:26264654)
• overexpressed miR-544a may be a promoter for breast cancer migration and invasion by targeting CDH1. (PMID:27053345)
• Study demonstrates that miR-544a regulates invasive and metastatic properties of colorectal cancer cells by modulating HOXA10 expression level both in vitro and in vivo. (PMID:27165435)
• MicroRNA-544 down-regulates both Bcl6 and Stat3 to inhibit tumor growth of human triple negative breast cancer (PMID:27186677)
• miR-544a expression was found to be modulated by selenium treatment, suggesting a possible role in SELK induction by selenium. (PMID:27275761)
• We found that inhibition of DICER processing of miR-544 through the use of a small molecule abolished miR-544 function in regulating adaptation of breast cancer cells to hypoxic stress. (PMID:27924483)
• TINCR suppressed proliferation and invasion through regulating miR-544a/FBXW7 axis in lung cancer. (PMID:29324317)
• deregulation of the miR-144-5p/ATF2 axis plays an important role in non-small-cell lung cancer cell radiosensitivity. (PMID:29850528)
• miR-544 may participate in controlling inflammation and apoptosis after ischemia-reperfusion by targeting IRAK4. (PMID:30229835)
• lncRNA GAS5 overexpression enhances the killing effect of NK cell on liver cancer through regulating miR-544/RUNX3 (PMID:30774011)
• LncRNA LEF1-AS1 regulates the migration and proliferation of vascular smooth muscle cells by targeting miR-544a/PTEN axis. (PMID:31016789)
• Renal expression of miR-544 is decreased in mice model of diabetic retinopathy. Also, it is demonstrated that miR-544 attenuates diabetic renal injury via suppressing glomerulosclerosis and inflammation by targeting FASN. (PMID:31323309)
• The up-regulation of miR-544a could be crucially involved in the GKN1 translational repression, thus suggesting its potential role as a biomarker and therapeutic target in gastric cancer patients. (PMID:31509760)
• miR-544 promotes maturity and antioxidation of stem cell-derived endothelial like cells by regulating the YY1/TET2 signalling axis. (PMID:32127022)
• miR-544a Stimulates endometrial carcinoma growth via targeted inhibition of reversion-inducing cysteine-rich protein with Kazal motifs. (PMID:32525042)
• circMIRIAF aggravates myocardial ischemia-reperfusion injury via targeting miR-544/WDR12 axis. (PMID:38795544)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gm54710	ENSMUSG00002075105
rattus_norvegicus	Mir544	ENSRNOG00000036487

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.