MIR544B

Summary

MIR544B (microRNA 544b, HGNC:38361) is a microRNA gene on chromosome 3q21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422864 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38361
Approved symbol	MIR544B
Name	microRNA 544b
Location	3q21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-544b
Ensembl gene	ENSG00000265981
Ensembl biotype	miRNA
Entrez	100422864
RNAcentral	URS000075E1F0 — miRNA, 78 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582372

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582372 — 1 exons

Exon	Start	End
ENSE00002724700	124732439	124732516

Expression profiles

Bgee: expression breadth broad, 91 present calls, max score 87.35.

Top tissues by expression

91 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	87.35	gold quality
bone marrow	UBERON:0002371	81.55	gold quality
lymph node	UBERON:0000029	79.93	gold quality
blood	UBERON:0000178	79.12	gold quality
endometrium	UBERON:0001295	78.93	gold quality
placenta	UBERON:0001987	76.00	gold quality
monocyte	CL:0000576	75.04	gold quality
kidney	UBERON:0002113	73.98	gold quality
muscle of leg	UBERON:0001383	73.84	gold quality
liver	UBERON:0002107	73.55	gold quality
gastrocnemius	UBERON:0001388	72.93	gold quality
heart left ventricle	UBERON:0002084	72.45	gold quality
calcaneal tendon	UBERON:0003701	72.38	gold quality
heart	UBERON:0000948	71.50	gold quality
adult mammalian kidney	UBERON:0000082	70.88	gold quality
amygdala	UBERON:0001876	70.74	gold quality
adrenal gland	UBERON:0002369	70.62	gold quality
body of pancreas	UBERON:0001150	70.48	gold quality
right lobe of liver	UBERON:0001114	69.99	gold quality
stomach	UBERON:0000945	69.94	gold quality
corpus callosum	UBERON:0002336	69.58	gold quality
myometrium	UBERON:0001296	69.18	gold quality
body of stomach	UBERON:0001161	68.54	gold quality
right atrium auricular region	UBERON:0006631	67.76	gold quality
left adrenal gland	UBERON:0001234	67.53	gold quality
descending thoracic aorta	UBERON:0002345	67.45	gold quality
right adrenal gland	UBERON:0001233	67.33	gold quality
left adrenal gland cortex	UBERON:0035825	67.13	gold quality
granulocyte	CL:0000094	67.05	gold quality
ascending aorta	UBERON:0001496	67.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• miR-544 promotes maturity and antioxidation of stem cell-derived endothelial like cells by regulating the YY1/TET2 signalling axis. (PMID:32127022)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.