MIR545

Summary

MIR545 (microRNA 545, HGNC:32531) is a microRNA gene on chromosome Xq13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 664614 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32531
Approved symbol	MIR545
Name	microRNA 545
Location	Xq13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-545
Ensembl gene	ENSG00000207820
Ensembl biotype	miRNA
Entrez	664614
RNAcentral	URS000075BCC5 — miRNA, 106 nt, 12 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385085

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385085 — 1 exons

Exon	Start	End
ENSE00001500091	74287104	74287209

Expression profiles

Bgee: expression breadth broad, 57 present calls, max score 80.36.

Top tissues by expression

57 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	80.36	gold quality
kidney	UBERON:0002113	79.85	gold quality
substantia nigra	UBERON:0002038	79.26	gold quality
adrenal tissue	UBERON:0018303	79.12	gold quality
gastrocnemius	UBERON:0001388	77.19	gold quality
monocyte	CL:0000576	75.67	gold quality
left coronary artery	UBERON:0001626	74.06	gold quality
heart	UBERON:0000948	73.16	gold quality
intestine	UBERON:0000160	73.05	gold quality
stomach	UBERON:0000945	72.44	gold quality
body of pancreas	UBERON:0001150	71.40	gold quality
urinary bladder	UBERON:0001255	71.18	gold quality
colon	UBERON:0001155	70.87	gold quality
body of stomach	UBERON:0001161	70.53	gold quality
endometrium	UBERON:0001295	70.53	gold quality
right adrenal gland	UBERON:0001233	70.45	gold quality
calcaneal tendon	UBERON:0003701	70.15	gold quality
left adrenal gland	UBERON:0001234	70.14	gold quality
lung	UBERON:0002048	69.90	gold quality
transverse colon	UBERON:0001157	69.83	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.65	gold quality
ascending aorta	UBERON:0001496	69.14	gold quality
skin of leg	UBERON:0001511	68.98	gold quality
right hemisphere of cerebellum	UBERON:0014890	68.58	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.53	gold quality
amygdala	UBERON:0001876	68.43	gold quality
left ovary	UBERON:0002119	68.42	gold quality
liver	UBERON:0002107	67.59	gold quality
right lobe of liver	UBERON:0001114	67.46	gold quality
skin of abdomen	UBERON:0001416	67.42	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 29)

• miR-545 suppressed cell proliferation by inhibiting the expression of cyclin D1 and CDK4. (PMID:24505359)
• The miR-545/374a cluster encoded in the Ftx lncRNA is overexpressed in HBV-related hepatocellular carcinoma and promotes tumorigenesis and tumor progression. (PMID:25299640)
• MiR-545 exerts its effects in pancreatic ductal adenocarcinoma by directly targeting RIG-1 (PMID:25315416)
• Data indicate that three microRNAs hsa-miR-146a, hsa-miR-148a and hsa-miR-545 targeting BRCA1/2 and were associated with overall survival and progression-free survival in patients with wild-type BRCA1/2. (PMID:25537514)
• Plasma miR-34a-5p and miR-545-3p may be early biomarkers of Alzheimer’s Disease (PMID:27631879)
• data suggested that HOTAIR long non-coding RNA mediates microR-545 regulating colorectal cancer cells proliferation. (PMID:28364379)
• MiR-545-3p, which served as a tumor promoter, post-transcriptionally regulate MT1M in HCC through binding to its untranslated region (3’UTR). (PMID:30227328)
• circ_0067934 promotes cervical cancer progression via miR-545/EIF3C axis. (PMID:30362562)
• results show that dysregulation of circPRKCI-miR-545/589-E2F7 axis mediated H2O2-induced neuronal cell injury; targeting this novel cascade could be a fine strategy to protect neurons from oxidative stress (PMID:31053300)
• circPRKCI promotes human glioma cell progression possibly by inhibiting miR-545. (PMID:31409777)
• Circular RNA circ-PRKCI promotes cell proliferation and invasion by binding to microRNA-545 in gastric cancer. (PMID:31773680)
• LINC00342 was over-expressed in colon adenocarcinoma (COAD) tissues and was related to the poor prognosis. LINC00342 knockdown inhibited cell proliferation, migration and invasion and promoted apoptosis of COAD cells. LINC00342 targeted to miR-545-5p/ MDM2 in COAD. In COAD tissues and cell lines, LINC00342 expression was positively correlated to MDM2 expression, while it was negatively correlated to miR-545-5p expression. (PMID:32213297)
• LncRNA AFAP1-AS1 contributes to the progression of endometrial carcinoma by regulating miR-545-3p/VEGFA pathway. (PMID:32504788)
• Long Noncoding RNASBF2-AS1 Promotes Gastric Cancer Progression via Regulating miR-545/EMS1 Axis. (PMID:32626753)
• Downregulation of hsa_circ_0007580 inhibits non-small cell lung cancer tumorigenesis by reducing miR-545-3p sponging. (PMID:32681720)
• Circular RNA PRKCI and microRNA-545 relate to sepsis risk, disease severity and 28-day mortality. (PMID:32985287)
• MicroRNA-545 suppresses progression of ovarian cancer through mediating PLK1 expression by a direct binding and an indirect regulation involving KDM4B-mediated demethylation. (PMID:33588776)
• C-X-C motif chemokine 16, modulated by microRNA-545, aggravates myocardial damage and affects the inflammatory responses in myocardial infarction. (PMID:33637127)
• Long Non-Coding RNA CASC2 Overexpression Ameliorates Sepsis-Associated Acute Kidney Injury by Regulating MiR-545-3p/PPARA Axis. (PMID:33957574)
• Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Proximal Tubular Epithelial Cells through miR-545-3p-TNFSF10. (PMID:34356656)
• Long non-coding RNA CASC9 promotes tumor progression in oral squamous cell carcinoma by regulating microRNA-545-3p/laminin subunit gamma 2. (PMID:34612783)
• Circular RNA intraflagellar transport 80 facilitates endometrial cancer progression through modulating miR-545-3p/FAM98A signaling. (PMID:34783205)
• Circular RNA UBR1 promotes the proliferation, migration, and invasion but represses apoptosis of lung cancer cells via modulating microRNA-545-5p/SSFA2 axis. (PMID:34787049)
• Shikonin induces cell autophagy via modulating the microRNA -545-3p/guanine nucleotide binding protein beta polypeptide 1 axis, thereby disrupting cellular carcinogenesis in colon cancer. (PMID:35192430)
• AFAP1 antisense RNA 1 promotes retinoblastoma progression by sponging microRNA miR-545-3p that targets G protein subunit beta 1. (PMID:35193469)
• Role of lncRNA FAM83H antisense RNA1 (FAM83H-AS1) in the progression of non-small cell lung cancer by regulating the miR-545-3p/heparan sulfate 6-O-sulfotransferase (HS6ST2) axis. (PMID:35260044)
• Knockdown of circ_0038467 alleviates lipopolysaccharides-induced 16HBE cell injury by regulating the miR-545-3p/TRAF1 axis in neonatal pneumonia. (PMID:36216207)
• Circ_0018909 knockdown inhibits the development of pancreatic cancer via the miR-545-3p/FASN axis and reduces macrophage polarization to M2. (PMID:36541402)
• Long non-coding TRPM2-AS regulates fracture healing by targeting miR-545-3p/Bmp2. (PMID:39118176)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.