MIR548A1

Summary

MIR548A1 (microRNA 548a-1, HGNC:32796) is a microRNA gene on chromosome 6p22.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693125 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32796
Approved symbol	MIR548A1
Name	microRNA 548a-1
Location	6p22.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548a-1
Ensembl gene	ENSG00000207775
Ensembl biotype	miRNA
Entrez	693125
RNAcentral	URS000075E715 — miRNA, 97 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385041

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385041 — 1 exons

Exon	Start	End
ENSE00001500048	18571784	18571880

Expression profiles

Bgee: expression breadth ubiquitous, 113 present calls, max score 88.27.

Top tissues by expression

113 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	88.27	gold quality
adrenal tissue	UBERON:0018303	86.43	gold quality
calcaneal tendon	UBERON:0003701	85.45	gold quality
bone marrow	UBERON:0002371	83.24	gold quality
endometrium	UBERON:0001295	82.76	gold quality
corpus callosum	UBERON:0002336	82.65	gold quality
duodenum	UBERON:0002114	81.64	gold quality
smooth muscle tissue	UBERON:0001135	81.48	gold quality
rectum	UBERON:0001052	80.60	gold quality
monocyte	CL:0000576	80.29	gold quality
blood	UBERON:0000178	80.19	gold quality
leukocyte	CL:0000738	79.84	gold quality
right uterine tube	UBERON:0001302	78.51	gold quality
body of pancreas	UBERON:0001150	78.19	gold quality
liver	UBERON:0002107	78.13	gold quality
stomach	UBERON:0000945	77.89	gold quality
pancreas	UBERON:0001264	77.36	gold quality
vermiform appendix	UBERON:0001154	76.32	gold quality
muscle of leg	UBERON:0001383	75.87	gold quality
body of stomach	UBERON:0001161	75.83	gold quality
placenta	UBERON:0001987	75.65	gold quality
tonsil	UBERON:0002372	75.61	gold quality
saliva-secreting gland	UBERON:0001044	75.46	gold quality
myometrium	UBERON:0001296	75.44	gold quality
minor salivary gland	UBERON:0001830	74.96	gold quality
right lobe of liver	UBERON:0001114	74.78	gold quality
gastrocnemius	UBERON:0001388	74.74	gold quality
islet of Langerhans	UBERON:0000006	74.58	gold quality
body of uterus	UBERON:0009853	74.28	gold quality
kidney	UBERON:0002113	74.22	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The oncogenic role of circ_0008450 was partially attributed to its suppression on miR-548p. (PMID:30556306)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.