MIR548A2

Summary

MIR548A2 (microRNA 548a-2, HGNC:32797) is a microRNA gene on chromosome 6q23.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693126 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32797
Approved symbol	MIR548A2
Name	microRNA 548a-2
Location	6q23.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548a-2
Ensembl gene	ENSG00000207689
Ensembl biotype	miRNA
Entrez	693126
RNAcentral	URS000075A142 — miRNA, 97 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384956

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384956 — 1 exons

Exon	Start	End
ENSE00001499963	135239160	135239256

Expression profiles

Bgee: expression breadth broad, 22 present calls, max score 73.26.

Top tissues by expression

22 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skin of leg	UBERON:0001511	73.26	gold quality
gastrocnemius	UBERON:0001388	72.51	gold quality
heart left ventricle	UBERON:0002084	68.56	gold quality
skin of abdomen	UBERON:0001416	68.19	gold quality
putamen	UBERON:0001874	67.40	gold quality
omental fat pad	UBERON:0010414	67.05	gold quality
blood	UBERON:0000178	66.66	gold quality
tibial artery	UBERON:0007610	66.07	gold quality
transverse colon	UBERON:0001157	64.91	gold quality
esophagus mucosa	UBERON:0002469	63.98	gold quality
anterior cingulate cortex	UBERON:0009835	63.22	gold quality
tibial nerve	UBERON:0001323	61.74	gold quality
small intestine Peyer’s patch	UBERON:0003454	61.20	gold quality
cerebellar hemisphere	UBERON:0002245	60.92	gold quality
thyroid gland	UBERON:0002046	60.15	gold quality
lung	UBERON:0002048	60.01	gold quality
Ammon’s horn	UBERON:0001954	59.50	gold quality
minor salivary gland	UBERON:0001830	58.98	gold quality
right frontal lobe	UBERON:0002810	50.60	gold quality
corpus callosum	UBERON:0002336	49.86	gold quality
right testis	UBERON:0004534	48.82	gold quality
left testis	UBERON:0004533	42.19	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The oncogenic role of circ_0008450 was partially attributed to its suppression on miR-548p. (PMID:30556306)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.