MIR548A3

Summary

MIR548A3 (microRNA 548a-3, HGNC:32798) is a microRNA gene on chromosome 8q22.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693127 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32798
Approved symbol	MIR548A3
Name	microRNA 548a-3
Location	8q22.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548a-3
Ensembl gene	ENSG00000208032
Ensembl biotype	miRNA
Entrez	693127
RNAcentral	URS000075E95F — miRNA, 97 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385297

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385297 — 1 exons

Exon	Start	End
ENSE00001500303	104484369	104484465

Expression profiles

Bgee: expression breadth broad, 74 present calls, max score 98.01.

Top tissues by expression

74 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	98.01	gold quality
skeletal muscle tissue	UBERON:0001134	82.41	gold quality
adrenal tissue	UBERON:0018303	79.71	gold quality
endometrium	UBERON:0001295	76.12	gold quality
monocyte	CL:0000576	74.73	gold quality
kidney	UBERON:0002113	74.26	gold quality
muscle of leg	UBERON:0001383	74.07	gold quality
islet of Langerhans	UBERON:0000006	74.04	gold quality
gastrocnemius	UBERON:0001388	73.66	gold quality
blood	UBERON:0000178	72.88	gold quality
stomach	UBERON:0000945	72.76	gold quality
liver	UBERON:0002107	72.67	gold quality
body of uterus	UBERON:0009853	72.32	gold quality
heart	UBERON:0000948	71.91	gold quality
right atrium auricular region	UBERON:0006631	71.58	gold quality
corpus callosum	UBERON:0002336	71.57	gold quality
lymph node	UBERON:0000029	71.56	gold quality
heart left ventricle	UBERON:0002084	70.60	gold quality
body of stomach	UBERON:0001161	70.52	gold quality
lung	UBERON:0002048	70.33	gold quality
body of pancreas	UBERON:0001150	69.93	gold quality
left adrenal gland cortex	UBERON:0035825	69.71	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.10	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.02	gold quality
putamen	UBERON:0001874	68.74	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.71	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.67	gold quality
ascending aorta	UBERON:0001496	68.63	gold quality
adult mammalian kidney	UBERON:0000082	68.54	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• The oncogenic role of circ_0008450 was partially attributed to its suppression on miR-548p. (PMID:30556306)
• miR-548a-3p Weakens the Tumorigenesis of Colon Cancer Through Targeting TPX2. (PMID:32857606)
• Circulating miR-455-3p, miR-5787, and miR-548a-3p as potential noninvasive biomarkers in the diagnosis of acute graft-versus-host disease: a validation study. (PMID:34247256)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.