MIR548AB

Summary

MIR548AB (microRNA 548ab, HGNC:41825) is a microRNA gene on chromosome 3q13.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616336 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41825
Approved symbol	MIR548AB
Name	microRNA 548ab
Location	3q13.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548ab
Ensembl gene	ENSG00000265328
Ensembl biotype	miRNA
Entrez	100616336
RNAcentral	URS000075A685 — miRNA, 84 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584917

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584917 — 1 exons

Exon	Start	End
ENSE00002684750	103524033	103524116

Expression profiles

Bgee: expression breadth tissue_specific, 9 present calls, max score 74.90.

Top tissues by expression

9 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endometrium	UBERON:0001295	74.90	gold quality
blood	UBERON:0000178	70.32	gold quality
esophagus mucosa	UBERON:0002469	64.63	gold quality
vagina	UBERON:0000996	63.97	gold quality
small intestine Peyer’s patch	UBERON:0003454	61.78	gold quality
hypothalamus	UBERON:0001898	61.31	gold quality
caudate nucleus	UBERON:0001873	57.53	gold quality
left lobe of thyroid gland	UBERON:0001120	54.02	gold quality
left testis	UBERON:0004533	48.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.