MIR548AC

Summary

MIR548AC (microRNA 548ac, HGNC:41626) is a microRNA gene on chromosome 1p13.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616384 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41626
Approved symbol	MIR548AC
Name	microRNA 548ac
Location	1p13.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548ac
Ensembl gene	ENSG00000264419
Ensembl biotype	miRNA
Entrez	100616384
RNAcentral	URS000075BB42 — miRNA, 88 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585049

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585049 — 1 exons

Exon	Start	End
ENSE00002696940	116560024	116560111

Expression profiles

Bgee: expression breadth broad, 97 present calls, max score 82.45.

Top tissues by expression

97 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.45	gold quality
bone marrow	UBERON:0002371	80.17	gold quality
monocyte	CL:0000576	77.99	gold quality
vermiform appendix	UBERON:0001154	77.99	gold quality
blood	UBERON:0000178	77.61	gold quality
lymph node	UBERON:0000029	77.03	gold quality
Brodmann (1909) area 9	UBERON:0013540	75.31	gold quality
kidney	UBERON:0002113	74.97	gold quality
endometrium	UBERON:0001295	74.89	gold quality
muscle of leg	UBERON:0001383	74.27	gold quality
granulocyte	CL:0000094	73.70	gold quality
adrenal tissue	UBERON:0018303	73.68	gold quality
gastrocnemius	UBERON:0001388	73.44	gold quality
heart left ventricle	UBERON:0002084	73.40	gold quality
cerebellar hemisphere	UBERON:0002245	73.32	gold quality
islet of Langerhans	UBERON:0000006	73.03	gold quality
right hemisphere of cerebellum	UBERON:0014890	72.84	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	72.68	gold quality
heart	UBERON:0000948	72.60	gold quality
adult mammalian kidney	UBERON:0000082	71.72	gold quality
stomach	UBERON:0000945	71.71	gold quality
hypothalamus	UBERON:0001898	71.51	gold quality
lower esophagus mucosa	UBERON:0035834	71.41	gold quality
cerebral cortex	UBERON:0000956	71.24	gold quality
liver	UBERON:0002107	71.03	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.02	gold quality
gall bladder	UBERON:0002110	70.72	gold quality
anterior cingulate cortex	UBERON:0009835	70.54	gold quality
right frontal lobe	UBERON:0002810	70.35	gold quality
frontal cortex	UBERON:0001870	70.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.85

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Linkage disequilibrium show evidence that mir-548ac rs1414273 variant is strongly associated with Multiple sclerosis (MS)-associated haplotype and confirms the single nucleotide polymorphisms within the first intron of CD58 been related too. [review] (PMID:25795118)
• Across different global populations and data sets, carriers of the multiple sclerosis risk allele showed reduced CD58 mRNA levels but increased hsa-miR-548ac levels. (PMID:30730892)
• Acute myeloid leukemia cell-derived extracellular vesicles carrying microRNA-548ac regulate hematopoietic function via the TRIM28/STAT3 pathway. (PMID:34453123)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.