MIR548AD

Summary

MIR548AD (microRNA 548ad, HGNC:41683) is a microRNA gene on chromosome 2p22.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616475 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41683
Approved symbol	MIR548AD
Name	microRNA 548ad
Location	2p22.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548ad
Ensembl gene	ENSG00000265301
Ensembl biotype	miRNA
Entrez	100616475
RNAcentral	URS000075C730 — miRNA, 82 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584780

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584780 — 1 exons

Exon	Start	End
ENSE00002696207	35471405	35471486

Expression profiles

Bgee: expression breadth broad, 82 present calls, max score 88.85.

Top tissues by expression

82 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	88.85	gold quality
bone marrow	UBERON:0002371	81.25	gold quality
adrenal tissue	UBERON:0018303	80.78	gold quality
endometrium	UBERON:0001295	76.94	gold quality
muscle of leg	UBERON:0001383	74.18	gold quality
right lobe of liver	UBERON:0001114	73.97	gold quality
gastrocnemius	UBERON:0001388	73.75	gold quality
blood	UBERON:0000178	72.74	gold quality
islet of Langerhans	UBERON:0000006	72.28	gold quality
gall bladder	UBERON:0002110	71.61	gold quality
placenta	UBERON:0001987	71.18	gold quality
body of stomach	UBERON:0001161	71.08	gold quality
stomach	UBERON:0000945	70.40	gold quality
left coronary artery	UBERON:0001626	69.68	gold quality
heart	UBERON:0000948	69.24	gold quality
heart left ventricle	UBERON:0002084	68.94	gold quality
right ovary	UBERON:0002118	68.64	gold quality
fallopian tube	UBERON:0003889	68.49	gold quality
right atrium auricular region	UBERON:0006631	68.28	gold quality
tibial artery	UBERON:0007610	68.08	gold quality
body of pancreas	UBERON:0001150	67.78	gold quality
skin of abdomen	UBERON:0001416	67.41	gold quality
zone of skin	UBERON:0000014	67.34	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.26	gold quality
skin of leg	UBERON:0001511	67.23	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.08	gold quality
rectum	UBERON:0001052	66.96	gold quality
Ammon’s horn	UBERON:0001954	66.95	gold quality
left adrenal gland	UBERON:0001234	66.80	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.74	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.