MIR548AE1

Summary

MIR548AE1 (microRNA 548ae-1, HGNC:41742) is a microRNA gene on chromosome 2q32.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616305 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41742
Approved symbol	MIR548AE1
Name	microRNA 548ae-1
Location	2q32.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548ae-1
Ensembl gene	ENSG00000266808
Ensembl biotype	miRNA
Entrez	100616305
RNAcentral	URS000075A3C5 — ncRNA, 70 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583292

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583292 — 1 exons

Exon	Start	End
ENSE00002687224	184378975	184379044

Expression profiles

Bgee: expression breadth broad, 13 present calls, max score 82.25.

Top tissues by expression

13 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.25	gold quality
adrenal tissue	UBERON:0018303	78.20	gold quality
blood	UBERON:0000178	75.33	gold quality
adult mammalian kidney	UBERON:0000082	69.84	gold quality
body of pancreas	UBERON:0001150	65.22	gold quality
cerebellar hemisphere	UBERON:0002245	65.19	gold quality
left lobe of thyroid gland	UBERON:0001120	61.81	gold quality
right frontal lobe	UBERON:0002810	61.40	gold quality
thyroid gland	UBERON:0002046	61.03	gold quality
pituitary gland	UBERON:0000007	56.57	gold quality
corpus callosum	UBERON:0002336	50.91	gold quality
right testis	UBERON:0004534	47.01	gold quality
left testis	UBERON:0004533	45.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (25): MIR548AA1 (ENSG00000207704), MIR579 (ENSG00000207956), MIR548P (ENSG00000221263), MIR548K (ENSG00000221333), MIR548F3 (ENSG00000221436), MIR548F1 (ENSG00000221594), MIR548N (ENSG00000221669), MIR548H3 (ENSG00000221698), MIR548AN (ENSG00000263515), MIR548X2 (ENSG00000263581), MIR548AX (ENSG00000263652), MIR548AS (ENSG00000263741), MIR548AV (ENSG00000263750), MIR548S (ENSG00000265056), MIR548AQ (ENSG00000265470), MIR548AG2 (ENSG00000265617), MIR548AJ1 (ENSG00000265669), MIR548AG1 (ENSG00000265829), MIR548X (ENSG00000265841), MIR548Z (ENSG00000266016), MIR548H5 (ENSG00000266807), MIR548O2 (ENSG00000275453), MIR548AY (ENSG00000276147), MIR548AZ (ENSG00000276479), MIR548AH (ENSG00000283682)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.