MIR548AE2

Summary

MIR548AE2 (microRNA 548ae-2, HGNC:41831) is a microRNA gene on chromosome 5q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616339 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41831
Approved symbol	MIR548AE2
Name	microRNA 548ae-2
Location	5q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548ae-2
Ensembl gene	ENSG00000265699
Ensembl biotype	miRNA
Entrez	100616339
RNAcentral	URS000075D567 — miRNA, 67 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583456

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583456 — 1 exons

Exon	Start	End
ENSE00002733147	58530043	58530109

Expression profiles

Bgee: expression breadth broad, 74 present calls, max score 86.52.

Top tissues by expression

74 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.52	gold quality
bone marrow	UBERON:0002371	82.46	gold quality
adrenal tissue	UBERON:0018303	80.08	gold quality
blood	UBERON:0000178	77.80	gold quality
liver	UBERON:0002107	77.35	gold quality
monocyte	CL:0000576	74.97	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	73.73	gold quality
endometrium	UBERON:0001295	73.46	gold quality
gastrocnemius	UBERON:0001388	73.22	gold quality
islet of Langerhans	UBERON:0000006	72.65	gold quality
kidney	UBERON:0002113	71.77	gold quality
body of pancreas	UBERON:0001150	71.06	gold quality
lung	UBERON:0002048	70.92	gold quality
tibial artery	UBERON:0007610	70.63	gold quality
heart left ventricle	UBERON:0002084	70.22	gold quality
heart	UBERON:0000948	70.10	gold quality
adult mammalian kidney	UBERON:0000082	69.52	gold quality
body of stomach	UBERON:0001161	69.33	gold quality
stomach	UBERON:0000945	68.96	gold quality
rectum	UBERON:0001052	68.69	gold quality
left coronary artery	UBERON:0001626	68.11	gold quality
right atrium auricular region	UBERON:0006631	68.07	gold quality
thoracic aorta	UBERON:0001515	67.78	gold quality
right lobe of liver	UBERON:0001114	67.76	gold quality
ascending aorta	UBERON:0001496	67.49	gold quality
skin of abdomen	UBERON:0001416	67.43	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.29	gold quality
zone of skin	UBERON:0000014	67.20	gold quality
adipose tissue	UBERON:0001013	67.02	gold quality
skin of leg	UBERON:0001511	66.99	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.