MIR548AG2

Summary

MIR548AG2 (microRNA 548ag-2, HGNC:41745) is a microRNA gene on chromosome 20q13.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616440 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41745
Approved symbol	MIR548AG2
Name	microRNA 548ag-2
Location	20q13.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548ag-2
Ensembl gene	ENSG00000265617
Ensembl biotype	miRNA
Entrez	100616440
RNAcentral	URS000075E818 — ncRNA, 64 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581228

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581228 — 1 exons

Exon	Start	End
ENSE00002695568	60564562	60564625

Expression profiles

Bgee: expression breadth broad, 57 present calls, max score 77.38.

Top tissues by expression

57 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gall bladder	UBERON:0002110	77.38	gold quality
liver	UBERON:0002107	75.98	gold quality
left adrenal gland cortex	UBERON:0035825	75.53	gold quality
blood	UBERON:0000178	74.28	gold quality
amygdala	UBERON:0001876	74.25	gold quality
heart	UBERON:0000948	74.00	gold quality
monocyte	CL:0000576	73.42	gold quality
gastrocnemius	UBERON:0001388	73.21	gold quality
stomach	UBERON:0000945	72.75	gold quality
heart left ventricle	UBERON:0002084	72.59	gold quality
islet of Langerhans	UBERON:0000006	72.14	gold quality
lung	UBERON:0002048	71.20	gold quality
body of stomach	UBERON:0001161	70.80	gold quality
left coronary artery	UBERON:0001626	70.57	gold quality
putamen	UBERON:0001874	69.91	gold quality
minor salivary gland	UBERON:0001830	69.86	gold quality
tibial artery	UBERON:0007610	68.88	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.76	gold quality
Ammon’s horn	UBERON:0001954	67.79	gold quality
transverse colon	UBERON:0001157	67.52	gold quality
anterior cingulate cortex	UBERON:0009835	67.20	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.82	gold quality
nucleus accumbens	UBERON:0001882	66.78	gold quality
ascending aorta	UBERON:0001496	66.70	gold quality
right lobe of thyroid gland	UBERON:0001119	66.44	gold quality
endometrium	UBERON:0001295	66.12	gold quality
esophagus mucosa	UBERON:0002469	65.80	gold quality
right frontal lobe	UBERON:0002810	65.69	gold quality
frontal cortex	UBERON:0001870	65.55	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.42	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• miR-548ag functions as an oncogene by suppressing MOB1B in the development of obesity-related endometrial cancer. (PMID:36445107)

Cross-species orthologs

0 orthologs

Paralogs (25): MIR548AA1 (ENSG00000207704), MIR579 (ENSG00000207956), MIR548P (ENSG00000221263), MIR548K (ENSG00000221333), MIR548F3 (ENSG00000221436), MIR548F1 (ENSG00000221594), MIR548N (ENSG00000221669), MIR548H3 (ENSG00000221698), MIR548AN (ENSG00000263515), MIR548X2 (ENSG00000263581), MIR548AX (ENSG00000263652), MIR548AS (ENSG00000263741), MIR548AV (ENSG00000263750), MIR548S (ENSG00000265056), MIR548AQ (ENSG00000265470), MIR548AJ1 (ENSG00000265669), MIR548AG1 (ENSG00000265829), MIR548X (ENSG00000265841), MIR548Z (ENSG00000266016), MIR548H5 (ENSG00000266807), MIR548AE1 (ENSG00000266808), MIR548O2 (ENSG00000275453), MIR548AY (ENSG00000276147), MIR548AZ (ENSG00000276479), MIR548AH (ENSG00000283682)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.