MIR548AH

Summary

MIR548AH (microRNA 548ah, HGNC:41605) is a microRNA gene on chromosome 4q21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616254 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41605
Approved symbol	MIR548AH
Name	microRNA 548ah
Location	4q21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548ah
Ensembl gene	ENSG00000283682
Ensembl biotype	miRNA
Entrez	100616254
RNAcentral	URS000075CCBF — ncRNA, 76 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637109

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637109 — 1 exons

Exon	Start	End
ENSE00003795979	76575551	76575626

Expression profiles

Bgee: expression breadth broad, 57 present calls, max score 76.72.

Top tissues by expression

57 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	76.72	gold quality
endometrium	UBERON:0001295	76.12	gold quality
right atrium auricular region	UBERON:0006631	70.99	gold quality
blood	UBERON:0000178	69.76	gold quality
right lobe of liver	UBERON:0001114	69.51	gold quality
substantia nigra	UBERON:0002038	69.19	gold quality
heart left ventricle	UBERON:0002084	69.12	gold quality
amygdala	UBERON:0001876	69.09	gold quality
nucleus accumbens	UBERON:0001882	68.41	gold quality
tibial artery	UBERON:0007610	68.32	gold quality
omental fat pad	UBERON:0010414	67.82	gold quality
stomach	UBERON:0000945	67.28	gold quality
granulocyte	CL:0000094	66.74	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.50	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.29	gold quality
ascending aorta	UBERON:0001496	65.63	gold quality
thoracic aorta	UBERON:0001515	65.55	gold quality
right adrenal gland cortex	UBERON:0035827	65.35	gold quality
skin of abdomen	UBERON:0001416	64.84	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.68	gold quality
transverse colon	UBERON:0001157	64.63	gold quality
esophagus mucosa	UBERON:0002469	64.58	gold quality
body of stomach	UBERON:0001161	64.32	gold quality
thoracic mammary gland	UBERON:0005200	64.30	gold quality
skin of leg	UBERON:0001511	64.15	gold quality
Brodmann (1909) area 9	UBERON:0013540	63.85	gold quality
putamen	UBERON:0001874	63.76	gold quality
multicellular organism	UBERON:0000468	63.57	gold quality
left lobe of thyroid gland	UBERON:0001120	63.32	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (25): MIR548AA1 (ENSG00000207704), MIR579 (ENSG00000207956), MIR548P (ENSG00000221263), MIR548K (ENSG00000221333), MIR548F3 (ENSG00000221436), MIR548F1 (ENSG00000221594), MIR548N (ENSG00000221669), MIR548H3 (ENSG00000221698), MIR548AN (ENSG00000263515), MIR548X2 (ENSG00000263581), MIR548AX (ENSG00000263652), MIR548AS (ENSG00000263741), MIR548AV (ENSG00000263750), MIR548S (ENSG00000265056), MIR548AQ (ENSG00000265470), MIR548AG2 (ENSG00000265617), MIR548AJ1 (ENSG00000265669), MIR548AG1 (ENSG00000265829), MIR548X (ENSG00000265841), MIR548Z (ENSG00000266016), MIR548H5 (ENSG00000266807), MIR548AE1 (ENSG00000266808), MIR548O2 (ENSG00000275453), MIR548AY (ENSG00000276147), MIR548AZ (ENSG00000276479)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.