MIR548AJ1

Summary

MIR548AJ1 (microRNA 548aj-1, HGNC:41884) is a microRNA gene on chromosome 6q23.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616191 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41884
Approved symbol	MIR548AJ1
Name	microRNA 548aj-1
Location	6q23.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548aj-1
Ensembl gene	ENSG00000265669
Ensembl biotype	miRNA
Entrez	100616191
RNAcentral	URS000075A869 — ncRNA, 72 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584644

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584644 — 1 exons

Exon	Start	End
ENSE00002696112	132115192	132115263

Expression profiles

Bgee: expression breadth broad, 32 present calls, max score 79.40.

Top tissues by expression

32 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
prostate gland	UBERON:0002367	79.40	gold quality
left lobe of thyroid gland	UBERON:0001120	76.07	gold quality
blood	UBERON:0000178	73.93	gold quality
gastrocnemius	UBERON:0001388	73.91	gold quality
monocyte	CL:0000576	73.21	gold quality
heart	UBERON:0000948	71.95	gold quality
calcaneal tendon	UBERON:0003701	71.88	gold quality
intestine	UBERON:0000160	71.32	gold quality
right atrium auricular region	UBERON:0006631	68.96	gold quality
thoracic mammary gland	UBERON:0005200	68.80	gold quality
myometrium	UBERON:0001296	67.52	gold quality
ascending aorta	UBERON:0001496	67.31	gold quality
thyroid gland	UBERON:0002046	67.11	gold quality
tibial artery	UBERON:0007610	66.37	gold quality
left ovary	UBERON:0002119	66.32	gold quality
lung	UBERON:0002048	65.75	gold quality
anterior cingulate cortex	UBERON:0009835	64.93	gold quality
skin of leg	UBERON:0001511	64.66	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.37	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.55	gold quality
skin of abdomen	UBERON:0001416	63.40	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	63.40	gold quality
transverse colon	UBERON:0001157	63.08	gold quality
minor salivary gland	UBERON:0001830	61.50	gold quality
spleen	UBERON:0002106	61.19	gold quality
right lung	UBERON:0002167	60.93	gold quality
cerebellar hemisphere	UBERON:0002245	60.74	gold quality
tibial nerve	UBERON:0001323	59.17	gold quality
vagina	UBERON:0000996	53.76	gold quality
right testis	UBERON:0004534	53.68	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (25): MIR548AA1 (ENSG00000207704), MIR579 (ENSG00000207956), MIR548P (ENSG00000221263), MIR548K (ENSG00000221333), MIR548F3 (ENSG00000221436), MIR548F1 (ENSG00000221594), MIR548N (ENSG00000221669), MIR548H3 (ENSG00000221698), MIR548AN (ENSG00000263515), MIR548X2 (ENSG00000263581), MIR548AX (ENSG00000263652), MIR548AS (ENSG00000263741), MIR548AV (ENSG00000263750), MIR548S (ENSG00000265056), MIR548AQ (ENSG00000265470), MIR548AG2 (ENSG00000265617), MIR548AG1 (ENSG00000265829), MIR548X (ENSG00000265841), MIR548Z (ENSG00000266016), MIR548H5 (ENSG00000266807), MIR548AE1 (ENSG00000266808), MIR548O2 (ENSG00000275453), MIR548AY (ENSG00000276147), MIR548AZ (ENSG00000276479), MIR548AH (ENSG00000283682)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.