MIR548AJ2

Summary

MIR548AJ2 (microRNA 548aj-2, HGNC:41600) is a microRNA gene on chromosome Xp11.4.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616252 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41600
Approved symbol	MIR548AJ2
Name	microRNA 548aj-2
Location	Xp11.4
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548aj-2
Ensembl gene	ENSG00000221466
Ensembl biotype	miRNA
Entrez	100616252
RNAcentral	URS000075A019 — miRNA, 92 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408539

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408539 — 1 exons

Exon	Start	End
ENSE00001565174	38023895	38023986

Expression profiles

Bgee: expression breadth broad, 93 present calls, max score 98.21.

Top tissues by expression

93 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	98.21	gold quality
adrenal tissue	UBERON:0018303	88.29	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.00	gold quality
calcaneal tendon	UBERON:0003701	84.56	gold quality
kidney	UBERON:0002113	82.11	gold quality
corpus callosum	UBERON:0002336	81.22	gold quality
adult mammalian kidney	UBERON:0000082	80.50	gold quality
blood	UBERON:0000178	78.24	gold quality
vermiform appendix	UBERON:0001154	77.97	gold quality
stomach	UBERON:0000945	77.75	gold quality
monocyte	CL:0000576	76.80	gold quality
bone marrow	UBERON:0002371	75.89	gold quality
endometrium	UBERON:0001295	75.31	gold quality
placenta	UBERON:0001987	74.13	gold quality
heart	UBERON:0000948	73.96	gold quality
gastrocnemius	UBERON:0001388	73.67	gold quality
liver	UBERON:0002107	73.23	gold quality
islet of Langerhans	UBERON:0000006	73.08	gold quality
lung	UBERON:0002048	71.25	gold quality
endocervix	UBERON:0000458	70.95	gold quality
heart left ventricle	UBERON:0002084	70.78	gold quality
left adrenal gland	UBERON:0001234	70.65	gold quality
right adrenal gland	UBERON:0001233	69.77	gold quality
left adrenal gland cortex	UBERON:0035825	69.75	gold quality
intestine	UBERON:0000160	69.70	gold quality
colon	UBERON:0001155	69.32	gold quality
body of stomach	UBERON:0001161	69.29	gold quality
body of pancreas	UBERON:0001150	69.28	gold quality
right atrium auricular region	UBERON:0006631	68.98	gold quality
tibial artery	UBERON:0007610	68.92	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.