MIR548AK

Summary

MIR548AK (microRNA 548ak, HGNC:41893) is a microRNA gene on chromosome 10p14.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616488 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41893
Approved symbol	MIR548AK
Name	microRNA 548ak
Location	10p14
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548ak
Ensembl gene	ENSG00000265653
Ensembl biotype	miRNA
Entrez	100616488
RNAcentral	URS000075EE12 — miRNA, 57 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584402

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584402 — 1 exons

Exon	Start	End
ENSE00002694626	12130760	12130816

Expression profiles

Bgee: expression breadth broad, 38 present calls, max score 80.77.

Top tissues by expression

38 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	80.77	gold quality
blood	UBERON:0000178	76.09	gold quality
endometrium	UBERON:0001295	74.47	gold quality
body of stomach	UBERON:0001161	74.39	gold quality
gastrocnemius	UBERON:0001388	73.63	gold quality
kidney	UBERON:0002113	72.09	gold quality
esophagus mucosa	UBERON:0002469	71.41	gold quality
vagina	UBERON:0000996	71.07	gold quality
right atrium auricular region	UBERON:0006631	70.64	gold quality
transverse colon	UBERON:0001157	68.47	gold quality
ascending aorta	UBERON:0001496	68.11	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.08	gold quality
omental fat pad	UBERON:0010414	67.94	gold quality
substantia nigra	UBERON:0002038	67.31	gold quality
body of pancreas	UBERON:0001150	66.42	gold quality
anterior cingulate cortex	UBERON:0009835	66.13	gold quality
right lobe of thyroid gland	UBERON:0001119	66.11	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.91	gold quality
amygdala	UBERON:0001876	65.33	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.18	gold quality
skin of abdomen	UBERON:0001416	65.15	gold quality
minor salivary gland	UBERON:0001830	65.15	gold quality
putamen	UBERON:0001874	65.13	gold quality
nucleus accumbens	UBERON:0001882	64.72	gold quality
right frontal lobe	UBERON:0002810	64.51	gold quality
thyroid gland	UBERON:0002046	64.40	gold quality
body of uterus	UBERON:0009853	64.27	gold quality
myometrium	UBERON:0001296	63.54	gold quality
caudate nucleus	UBERON:0001873	63.37	gold quality
adult mammalian kidney	UBERON:0000082	62.74	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MiR-548 K regulatory effect on the ABCG2 gene expression in MDR breast cancer cells. (PMID:37166017)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.