MIR548AL

Summary

MIR548AL (microRNA 548al, HGNC:41736) is a microRNA gene on chromosome 11q13.4.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616215 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41736
Approved symbol	MIR548AL
Name	microRNA 548al
Location	11q13.4
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548al
Ensembl gene	ENSG00000264402
Ensembl biotype	miRNA
Entrez	100616215
RNAcentral	URS000075CCD2 — miRNA, 97 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578416

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578416 — 1 exons

Exon	Start	End
ENSE00002723719	74399237	74399333

Expression profiles

Bgee: expression breadth broad, 87 present calls, max score 83.36.

Top tissues by expression

87 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	83.36	gold quality
duodenum	UBERON:0002114	78.37	gold quality
endometrium	UBERON:0001295	77.12	gold quality
vermiform appendix	UBERON:0001154	77.01	gold quality
adrenal tissue	UBERON:0018303	75.81	gold quality
monocyte	CL:0000576	75.17	gold quality
blood	UBERON:0000178	74.20	gold quality
placenta	UBERON:0001987	74.10	gold quality
gastrocnemius	UBERON:0001388	73.84	gold quality
islet of Langerhans	UBERON:0000006	73.46	gold quality
bone marrow	UBERON:0002371	73.27	gold quality
pancreas	UBERON:0001264	72.63	gold quality
body of pancreas	UBERON:0001150	72.11	gold quality
kidney	UBERON:0002113	71.56	gold quality
heart	UBERON:0000948	70.92	gold quality
heart left ventricle	UBERON:0002084	70.60	gold quality
adult mammalian kidney	UBERON:0000082	70.07	gold quality
liver	UBERON:0002107	69.92	gold quality
left coronary artery	UBERON:0001626	69.47	gold quality
right adrenal gland	UBERON:0001233	69.23	gold quality
tibial artery	UBERON:0007610	69.07	gold quality
stomach	UBERON:0000945	69.02	gold quality
left uterine tube	UBERON:0001303	68.76	gold quality
granulocyte	CL:0000094	68.68	gold quality
body of stomach	UBERON:0001161	68.41	gold quality
right atrium auricular region	UBERON:0006631	68.25	gold quality
gall bladder	UBERON:0002110	68.17	gold quality
substantia nigra	UBERON:0002038	68.06	gold quality
thoracic aorta	UBERON:0001515	68.04	gold quality
anterior cingulate cortex	UBERON:0009835	68.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.