MIR548AM

Summary

MIR548AM (microRNA 548am, HGNC:41637) is a microRNA gene on chromosome Xp22.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616428 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41637
Approved symbol	MIR548AM
Name	microRNA 548am
Location	Xp22.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548am
Ensembl gene	ENSG00000265144
Ensembl biotype	miRNA
Entrez	100616428
RNAcentral	URS000075EC75 — miRNA, 74 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584298

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584298 — 1 exons

Exon	Start	End
ENSE00002700690	16627012	16627085

Expression profiles

Bgee: expression breadth broad, 66 present calls, max score 76.22.

Top tissues by expression

66 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endometrium	UBERON:0001295	76.22	gold quality
islet of Langerhans	UBERON:0000006	74.72	gold quality
muscle of leg	UBERON:0001383	74.27	gold quality
stomach	UBERON:0000945	73.00	gold quality
blood	UBERON:0000178	72.07	gold quality
monocyte	CL:0000576	71.04	gold quality
gastrocnemius	UBERON:0001388	70.34	gold quality
right adrenal gland	UBERON:0001233	69.29	gold quality
heart	UBERON:0000948	69.05	gold quality
thoracic mammary gland	UBERON:0005200	69.00	gold quality
heart left ventricle	UBERON:0002084	68.79	gold quality
right lobe of liver	UBERON:0001114	68.44	gold quality
fundus of stomach	UBERON:0001160	68.19	gold quality
body of stomach	UBERON:0001161	68.18	gold quality
liver	UBERON:0002107	67.91	gold quality
right atrium auricular region	UBERON:0006631	67.71	gold quality
lung	UBERON:0002048	67.30	gold quality
tibial artery	UBERON:0007610	67.12	gold quality
body of pancreas	UBERON:0001150	66.71	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.45	gold quality
ascending aorta	UBERON:0001496	66.36	gold quality
left coronary artery	UBERON:0001626	66.06	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.86	gold quality
amygdala	UBERON:0001876	65.69	gold quality
skin of leg	UBERON:0001511	65.68	gold quality
body of uterus	UBERON:0009853	65.42	gold quality
adult mammalian kidney	UBERON:0000082	65.06	gold quality
transverse colon	UBERON:0001157	64.76	gold quality
right hemisphere of cerebellum	UBERON:0014890	64.69	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• miR548am-5p can account for sex-dependent differences observed in the susceptibility to mitochondrial apoptosis of human dermal fibroblasts. (PMID:31511496)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.