MIR548AN

Summary

MIR548AN (microRNA 548an, HGNC:41681) is a microRNA gene on chromosome Xq22.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616144 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41681
Approved symbol	MIR548AN
Name	microRNA 548an
Location	Xq22.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548an
Ensembl gene	ENSG00000263515
Ensembl biotype	miRNA
Entrez	100616144
RNAcentral	URS000075D50C — miRNA, 83 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408286

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408286 — 1 exons

Exon	Start	End
ENSE00002728398	106639814	106639896

Expression profiles

Bgee: expression breadth broad, 92 present calls, max score 80.17.

Top tissues by expression

92 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
placenta	UBERON:0001987	80.17	gold quality
vermiform appendix	UBERON:0001154	79.49	gold quality
endometrium	UBERON:0001295	76.79	gold quality
muscle of leg	UBERON:0001383	74.46	gold quality
adrenal tissue	UBERON:0018303	74.17	gold quality
gastrocnemius	UBERON:0001388	74.07	gold quality
lymph node	UBERON:0000029	73.82	gold quality
monocyte	CL:0000576	73.54	gold quality
islet of Langerhans	UBERON:0000006	72.74	gold quality
blood	UBERON:0000178	72.57	gold quality
right coronary artery	UBERON:0001625	71.92	gold quality
pituitary gland	UBERON:0000007	70.80	gold quality
body of stomach	UBERON:0001161	70.13	gold quality
stomach	UBERON:0000945	70.00	gold quality
right lobe of liver	UBERON:0001114	69.94	gold quality
liver	UBERON:0002107	69.68	gold quality
urinary bladder	UBERON:0001255	69.65	gold quality
adult mammalian kidney	UBERON:0000082	69.06	gold quality
heart left ventricle	UBERON:0002084	68.96	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	68.95	gold quality
tonsil	UBERON:0002372	68.77	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.77	gold quality
heart	UBERON:0000948	68.58	gold quality
left uterine tube	UBERON:0001303	68.47	gold quality
body of pancreas	UBERON:0001150	68.28	gold quality
adrenal gland	UBERON:0002369	68.27	gold quality
left ovary	UBERON:0002119	68.22	gold quality
right ovary	UBERON:0002118	68.21	gold quality
left adrenal gland	UBERON:0001234	68.13	gold quality
endocervix	UBERON:0000458	67.86	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.15

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• This study provided evidence that miRNA-548an is involved in the regulation of NS1ABP. (PMID:24210102)

Cross-species orthologs

0 orthologs

Paralogs (25): MIR548AA1 (ENSG00000207704), MIR579 (ENSG00000207956), MIR548P (ENSG00000221263), MIR548K (ENSG00000221333), MIR548F3 (ENSG00000221436), MIR548F1 (ENSG00000221594), MIR548N (ENSG00000221669), MIR548H3 (ENSG00000221698), MIR548X2 (ENSG00000263581), MIR548AX (ENSG00000263652), MIR548AS (ENSG00000263741), MIR548AV (ENSG00000263750), MIR548S (ENSG00000265056), MIR548AQ (ENSG00000265470), MIR548AG2 (ENSG00000265617), MIR548AJ1 (ENSG00000265669), MIR548AG1 (ENSG00000265829), MIR548X (ENSG00000265841), MIR548Z (ENSG00000266016), MIR548H5 (ENSG00000266807), MIR548AE1 (ENSG00000266808), MIR548O2 (ENSG00000275453), MIR548AY (ENSG00000276147), MIR548AZ (ENSG00000276479), MIR548AH (ENSG00000283682)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.