MIR548AO

Summary

MIR548AO (microRNA 548ao, HGNC:43539) is a microRNA gene on chromosome 8p11.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847068 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43539
Approved symbol	MIR548AO
Name	microRNA 548ao
Location	8p11.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548ao
Ensembl gene	ENSG00000263372
Ensembl biotype	miRNA
Entrez	100847068
RNAcentral	URS000075B786 — miRNA, 96 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579992

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579992 — 1 exons

Exon	Start	End
ENSE00002725747	41271048	41271143

Expression profiles

Bgee: expression breadth broad, 54 present calls, max score 83.38.

Top tissues by expression

54 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.38	gold quality
blood	UBERON:0000178	81.26	gold quality
monocyte	CL:0000576	79.90	gold quality
adrenal tissue	UBERON:0018303	76.23	gold quality
endometrium	UBERON:0001295	74.17	gold quality
heart	UBERON:0000948	72.97	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	72.94	gold quality
right atrium auricular region	UBERON:0006631	72.82	gold quality
stomach	UBERON:0000945	72.58	gold quality
gastrocnemius	UBERON:0001388	72.51	gold quality
tibial artery	UBERON:0007610	70.49	gold quality
kidney	UBERON:0002113	70.47	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.60	gold quality
ascending aorta	UBERON:0001496	68.88	gold quality
left adrenal gland	UBERON:0001234	68.76	gold quality
right hemisphere of cerebellum	UBERON:0014890	67.83	gold quality
tibial nerve	UBERON:0001323	67.54	gold quality
saliva-secreting gland	UBERON:0001044	67.51	gold quality
intestine	UBERON:0000160	67.35	gold quality
body of pancreas	UBERON:0001150	67.32	gold quality
minor salivary gland	UBERON:0001830	66.94	gold quality
vagina	UBERON:0000996	66.75	gold quality
esophagus mucosa	UBERON:0002469	66.64	gold quality
skin of abdomen	UBERON:0001416	66.57	gold quality
heart left ventricle	UBERON:0002084	66.14	gold quality
skin of leg	UBERON:0001511	65.69	gold quality
right lobe of thyroid gland	UBERON:0001119	65.52	gold quality
body of uterus	UBERON:0009853	65.42	gold quality
right ovary	UBERON:0002118	65.36	gold quality
colon	UBERON:0001155	65.14	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.99

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• RP11156L14.1 regulates SSR1 expression by competitively binding to miR548ao3p in hypopharyngeal squamous cell carcinoma. (PMID:33000261)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.