MIR548AP

Summary

MIR548AP (microRNA 548ap, HGNC:43465) is a microRNA gene on chromosome 15q25.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847084 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43465
Approved symbol	MIR548AP
Name	microRNA 548ap
Location	15q25.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548ap
Ensembl gene	ENSG00000264406
Ensembl biotype	miRNA
Entrez	100847084
RNAcentral	URS000075CF26 — miRNA, 96 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584739

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584739 — 1 exons

Exon	Start	End
ENSE00002711343	85825635	85825730

Expression profiles

Bgee: expression breadth broad, 23 present calls, max score 70.98.

Top tissues by expression

23 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	70.98	gold quality
body of stomach	UBERON:0001161	70.18	gold quality
esophagus mucosa	UBERON:0002469	68.66	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.34	gold quality
vagina	UBERON:0000996	66.17	gold quality
omental fat pad	UBERON:0010414	66.11	gold quality
ascending aorta	UBERON:0001496	66.00	gold quality
right hemisphere of cerebellum	UBERON:0014890	65.51	gold quality
skin of leg	UBERON:0001511	65.44	gold quality
cerebellar hemisphere	UBERON:0002245	65.00	gold quality
anterior cingulate cortex	UBERON:0009835	64.98	gold quality
Ammon’s horn	UBERON:0001954	64.81	gold quality
skin of abdomen	UBERON:0001416	63.94	gold quality
transverse colon	UBERON:0001157	62.95	gold quality
left lobe of thyroid gland	UBERON:0001120	62.68	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.62	gold quality
small intestine Peyer’s patch	UBERON:0003454	61.34	gold quality
thoracic mammary gland	UBERON:0005200	60.00	gold quality
right frontal lobe	UBERON:0002810	59.91	gold quality
pituitary gland	UBERON:0000007	59.25	gold quality
Brodmann (1909) area 9	UBERON:0013540	58.91	gold quality
hypothalamus	UBERON:0001898	39.98	gold quality
left testis	UBERON:0004533	39.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.99

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.