MIR548AQ

Summary

MIR548AQ (microRNA 548aq, HGNC:43488) is a microRNA gene on chromosome 3q27.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847078 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43488
Approved symbol	MIR548AQ
Name	microRNA 548aq
Location	3q27.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548aq
Ensembl gene	ENSG00000265470
Ensembl biotype	miRNA
Entrez	100847078
RNAcentral	URS000075DBF5 — ncRNA, 58 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580207

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580207 — 1 exons

Exon	Start	End
ENSE00002685585	185767847	185767904

Expression profiles

Bgee: expression breadth broad, 91 present calls, max score 90.08.

Top tissues by expression

91 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	90.08	gold quality
adrenal tissue	UBERON:0018303	81.76	gold quality
bone marrow	UBERON:0002371	80.93	gold quality
placenta	UBERON:0001987	77.20	gold quality
monocyte	CL:0000576	76.05	gold quality
blood	UBERON:0000178	75.99	gold quality
muscle of leg	UBERON:0001383	75.76	gold quality
calcaneal tendon	UBERON:0003701	75.68	gold quality
liver	UBERON:0002107	74.94	gold quality
islet of Langerhans	UBERON:0000006	74.84	gold quality
stomach	UBERON:0000945	74.56	gold quality
urinary bladder	UBERON:0001255	74.05	gold quality
gastrocnemius	UBERON:0001388	73.95	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	73.92	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	73.13	gold quality
rectum	UBERON:0001052	72.49	gold quality
heart	UBERON:0000948	72.47	gold quality
tibial artery	UBERON:0007610	72.09	gold quality
kidney	UBERON:0002113	72.03	gold quality
endometrium	UBERON:0001295	72.00	gold quality
ectocervix	UBERON:0012249	71.83	gold quality
heart left ventricle	UBERON:0002084	71.68	gold quality
tonsil	UBERON:0002372	71.31	gold quality
adrenal gland	UBERON:0002369	71.12	gold quality
lung	UBERON:0002048	71.11	gold quality
body of stomach	UBERON:0001161	70.96	gold quality
right lobe of liver	UBERON:0001114	70.84	gold quality
substantia nigra	UBERON:0002038	70.76	gold quality
lymph node	UBERON:0000029	70.74	gold quality
colon	UBERON:0001155	70.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• miR-548aq-3p is a novel target of Far infrared radiation which predicts coronary artery disease endothelial colony forming cell responsiveness. (PMID:32322002)
• Downregulated miR-367-3p, miR-548aq-5p, and miR-4710 in Human Whole Blood: Potential Biomarkers for Breast Cancer With Axillary Lymph Node Metastasis. (PMID:36564279)

Cross-species orthologs

0 orthologs

Paralogs (25): MIR548AA1 (ENSG00000207704), MIR579 (ENSG00000207956), MIR548P (ENSG00000221263), MIR548K (ENSG00000221333), MIR548F3 (ENSG00000221436), MIR548F1 (ENSG00000221594), MIR548N (ENSG00000221669), MIR548H3 (ENSG00000221698), MIR548AN (ENSG00000263515), MIR548X2 (ENSG00000263581), MIR548AX (ENSG00000263652), MIR548AS (ENSG00000263741), MIR548AV (ENSG00000263750), MIR548S (ENSG00000265056), MIR548AG2 (ENSG00000265617), MIR548AJ1 (ENSG00000265669), MIR548AG1 (ENSG00000265829), MIR548X (ENSG00000265841), MIR548Z (ENSG00000266016), MIR548H5 (ENSG00000266807), MIR548AE1 (ENSG00000266808), MIR548O2 (ENSG00000275453), MIR548AY (ENSG00000276147), MIR548AZ (ENSG00000276479), MIR548AH (ENSG00000283682)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.