MIR548AR

Summary

MIR548AR (microRNA 548ar, HGNC:43455) is a microRNA gene on chromosome 13q34.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847035 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43455
Approved symbol	MIR548AR
Name	microRNA 548ar
Location	13q34
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548ar
Ensembl gene	ENSG00000264539
Ensembl biotype	miRNA
Entrez	100847035
RNAcentral	URS000075D74C — miRNA, 57 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582191

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582191 — 1 exons

Exon	Start	End
ENSE00002708344	114244505	114244561

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 90.21.

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	90.21	gold quality
duodenum	UBERON:0002114	82.13	gold quality
lymph node	UBERON:0000029	79.95	gold quality
right coronary artery	UBERON:0001625	79.82	gold quality
myometrium	UBERON:0001296	78.54	gold quality
skin of abdomen	UBERON:0001416	78.29	gold quality
endocervix	UBERON:0000458	78.24	gold quality
zone of skin	UBERON:0000014	77.96	gold quality
skin of leg	UBERON:0001511	77.73	gold quality
fundus of stomach	UBERON:0001160	77.49	gold quality
ectocervix	UBERON:0012249	77.47	gold quality
subcutaneous adipose tissue	UBERON:0002190	76.67	gold quality
tibial nerve	UBERON:0001323	76.62	gold quality
body of uterus	UBERON:0009853	76.57	gold quality
popliteal artery	UBERON:0002250	76.44	gold quality
tibial artery	UBERON:0007610	76.38	gold quality
right ovary	UBERON:0002118	76.37	gold quality
ovary	UBERON:0000992	76.30	gold quality
left ovary	UBERON:0002119	76.29	gold quality
blood	UBERON:0000178	76.25	gold quality
gastrocnemius	UBERON:0001388	76.24	gold quality
right lobe of liver	UBERON:0001114	76.05	gold quality
mucosa of stomach	UBERON:0001199	75.91	gold quality
adrenal tissue	UBERON:0018303	75.83	gold quality
ascending aorta	UBERON:0001496	75.60	gold quality
thoracic mammary gland	UBERON:0005200	75.52	gold quality
thoracic aorta	UBERON:0001515	75.51	gold quality
body of pancreas	UBERON:0001150	75.26	gold quality
right atrium auricular region	UBERON:0006631	75.08	gold quality
calcaneal tendon	UBERON:0003701	75.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.77

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Down-regulation of miR-7-5p and miR-548ar-5p predicts malignancy in indeterminate thyroid nodules negative for BRAF and RAS mutations. (PMID:35347579)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.