MIR548AS

Summary

MIR548AS (microRNA 548as, HGNC:43550) is a microRNA gene on chromosome 13q31.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847092 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43550
Approved symbol	MIR548AS
Name	microRNA 548as
Location	13q31.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548as
Ensembl gene	ENSG00000263741
Ensembl biotype	miRNA
Entrez	100847092
RNAcentral	URS000075A16B — ncRNA, 58 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579177

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579177 — 1 exons

Exon	Start	End
ENSE00002687338	92490163	92490220

Expression profiles

Bgee: expression breadth broad, 20 present calls, max score 83.94.

Top tissues by expression

20 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lung	UBERON:0002048	83.94	gold quality
kidney	UBERON:0002113	79.85	gold quality
adrenal tissue	UBERON:0018303	76.03	gold quality
liver	UBERON:0002107	75.85	gold quality
calcaneal tendon	UBERON:0003701	74.39	gold quality
heart	UBERON:0000948	72.44	gold quality
adult mammalian kidney	UBERON:0000082	70.48	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.44	gold quality
right atrium auricular region	UBERON:0006631	67.14	gold quality
caudate nucleus	UBERON:0001873	66.54	gold quality
vagina	UBERON:0000996	66.51	gold quality
skin of leg	UBERON:0001511	65.59	gold quality
colon	UBERON:0001155	65.12	gold quality
putamen	UBERON:0001874	64.44	gold quality
pituitary gland	UBERON:0000007	64.16	gold quality
nucleus accumbens	UBERON:0001882	63.64	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.53	gold quality
corpus callosum	UBERON:0002336	62.01	gold quality
left testis	UBERON:0004533	46.54	gold quality
right testis	UBERON:0004534	46.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (25): MIR548AA1 (ENSG00000207704), MIR579 (ENSG00000207956), MIR548P (ENSG00000221263), MIR548K (ENSG00000221333), MIR548F3 (ENSG00000221436), MIR548F1 (ENSG00000221594), MIR548N (ENSG00000221669), MIR548H3 (ENSG00000221698), MIR548AN (ENSG00000263515), MIR548X2 (ENSG00000263581), MIR548AX (ENSG00000263652), MIR548AV (ENSG00000263750), MIR548S (ENSG00000265056), MIR548AQ (ENSG00000265470), MIR548AG2 (ENSG00000265617), MIR548AJ1 (ENSG00000265669), MIR548AG1 (ENSG00000265829), MIR548X (ENSG00000265841), MIR548Z (ENSG00000266016), MIR548H5 (ENSG00000266807), MIR548AE1 (ENSG00000266808), MIR548O2 (ENSG00000275453), MIR548AY (ENSG00000276147), MIR548AZ (ENSG00000276479), MIR548AH (ENSG00000283682)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.