MIR548AT

Summary

MIR548AT (microRNA 548at, HGNC:43517) is a microRNA gene on chromosome 17q21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847030 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43517
Approved symbol	MIR548AT
Name	microRNA 548at
Location	17q21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548at
Ensembl gene	ENSG00000264314
Ensembl biotype	miRNA
Entrez	100847030
RNAcentral	URS000075E451 — miRNA, 58 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578714

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578714 — 1 exons

Exon	Start	End
ENSE00002705542	42494773	42494830

Expression profiles

Bgee: expression breadth broad, 83 present calls, max score 81.84.

Top tissues by expression

83 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	81.84	gold quality
blood	UBERON:0000178	77.82	gold quality
muscle of leg	UBERON:0001383	75.80	gold quality
monocyte	CL:0000576	74.81	gold quality
gastrocnemius	UBERON:0001388	74.44	gold quality
liver	UBERON:0002107	74.37	gold quality
endometrium	UBERON:0001295	73.79	gold quality
rectum	UBERON:0001052	73.29	gold quality
heart left ventricle	UBERON:0002084	73.18	gold quality
islet of Langerhans	UBERON:0000006	72.23	gold quality
ectocervix	UBERON:0012249	71.83	gold quality
heart	UBERON:0000948	71.67	gold quality
right frontal lobe	UBERON:0002810	71.09	gold quality
left adrenal gland cortex	UBERON:0035825	70.44	gold quality
body of pancreas	UBERON:0001150	70.41	gold quality
right atrium auricular region	UBERON:0006631	70.36	gold quality
stomach	UBERON:0000945	70.18	gold quality
urinary bladder	UBERON:0001255	69.76	gold quality
tibial artery	UBERON:0007610	69.73	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.34	gold quality
body of stomach	UBERON:0001161	69.18	gold quality
kidney	UBERON:0002113	68.69	gold quality
left adrenal gland	UBERON:0001234	68.59	gold quality
intestine	UBERON:0000160	68.52	gold quality
right lobe of liver	UBERON:0001114	68.48	gold quality
right coronary artery	UBERON:0001625	68.48	gold quality
ascending aorta	UBERON:0001496	68.30	gold quality
esophagus mucosa	UBERON:0002469	68.27	gold quality
transverse colon	UBERON:0001157	68.20	gold quality
lower esophagus	UBERON:0013473	68.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.22

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• This study demonstrated that miR-548at-5p were not associated to PD, which suggest they may not contribute to the gene susceptibility of PD at least in Chinese Han population. (PMID:29209904)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.