MIR548AU

Summary

MIR548AU (microRNA 548au, HGNC:43483) is a microRNA gene on chromosome 9q22.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847045 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43483
Approved symbol	MIR548AU
Name	microRNA 548au
Location	9q22.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548au
Ensembl gene	ENSG00000283146
Ensembl biotype	miRNA
Entrez	100847045
RNAcentral	URS000075B121 — miRNA, 54 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637016

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637016 — 1 exons

Exon	Start	End
ENSE00003800592	93594841	93594894

Expression profiles

Bgee: expression breadth broad, 35 present calls, max score 81.98.

Top tissues by expression

35 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lung	UBERON:0002048	81.98	gold quality
blood	UBERON:0000178	76.76	gold quality
liver	UBERON:0002107	75.61	gold quality
right frontal lobe	UBERON:0002810	75.49	gold quality
gastrocnemius	UBERON:0001388	74.32	gold quality
body of stomach	UBERON:0001161	72.95	gold quality
stomach	UBERON:0000945	72.70	gold quality
monocyte	CL:0000576	72.42	gold quality
intestine	UBERON:0000160	71.88	gold quality
kidney	UBERON:0002113	71.56	gold quality
transverse colon	UBERON:0001157	71.38	gold quality
heart left ventricle	UBERON:0002084	71.20	gold quality
nucleus accumbens	UBERON:0001882	70.21	gold quality
tibial nerve	UBERON:0001323	69.97	gold quality
Ammon’s horn	UBERON:0001954	69.79	gold quality
thoracic mammary gland	UBERON:0005200	68.42	gold quality
colon	UBERON:0001155	68.39	gold quality
left ovary	UBERON:0002119	67.92	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.88	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.85	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.73	gold quality
skin of abdomen	UBERON:0001416	66.60	gold quality
endometrium	UBERON:0001295	65.95	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.64	gold quality
left adrenal gland cortex	UBERON:0035825	65.54	gold quality
cerebellar hemisphere	UBERON:0002245	65.35	gold quality
skin of leg	UBERON:0001511	64.99	gold quality
esophagus mucosa	UBERON:0002469	64.96	gold quality
right hemisphere of cerebellum	UBERON:0014890	64.81	gold quality
hypothalamus	UBERON:0001898	64.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.29

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.