MIR548AV

Summary

MIR548AV (microRNA 548av, HGNC:43537) is a microRNA gene on chromosome 18q22.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847083 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43537
Approved symbol	MIR548AV
Name	microRNA 548av
Location	18q22.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548av
Ensembl gene	ENSG00000263750
Ensembl biotype	miRNA
Entrez	100847083
RNAcentral	URS000075D420 — ncRNA, 62 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583040

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583040 — 1 exons

Exon	Start	End
ENSE00002733225	72853321	72853382

Expression profiles

Bgee: expression breadth broad, 12 present calls, max score 66.60.

Top tissues by expression

12 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
thoracic mammary gland	UBERON:0005200	66.60	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.80	gold quality
Ammon’s horn	UBERON:0001954	64.76	gold quality
right frontal lobe	UBERON:0002810	64.72	gold quality
caudate nucleus	UBERON:0001873	63.65	gold quality
spleen	UBERON:0002106	62.89	gold quality
anterior cingulate cortex	UBERON:0009835	62.50	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.14	gold quality
Brodmann (1909) area 9	UBERON:0013540	61.52	gold quality
left lobe of thyroid gland	UBERON:0001120	59.08	gold quality
corpus callosum	UBERON:0002336	58.03	gold quality
tibial nerve	UBERON:0001323	57.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.99

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (25): MIR548AA1 (ENSG00000207704), MIR579 (ENSG00000207956), MIR548P (ENSG00000221263), MIR548K (ENSG00000221333), MIR548F3 (ENSG00000221436), MIR548F1 (ENSG00000221594), MIR548N (ENSG00000221669), MIR548H3 (ENSG00000221698), MIR548AN (ENSG00000263515), MIR548X2 (ENSG00000263581), MIR548AX (ENSG00000263652), MIR548AS (ENSG00000263741), MIR548S (ENSG00000265056), MIR548AQ (ENSG00000265470), MIR548AG2 (ENSG00000265617), MIR548AJ1 (ENSG00000265669), MIR548AG1 (ENSG00000265829), MIR548X (ENSG00000265841), MIR548Z (ENSG00000266016), MIR548H5 (ENSG00000266807), MIR548AE1 (ENSG00000266808), MIR548O2 (ENSG00000275453), MIR548AY (ENSG00000276147), MIR548AZ (ENSG00000276479), MIR548AH (ENSG00000283682)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.