MIR548AW

Summary

MIR548AW (microRNA 548aw, HGNC:43454) is a microRNA gene on chromosome 9q34.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100846992 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43454
Approved symbol	MIR548AW
Name	microRNA 548aw
Location	9q34.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548aw
Ensembl gene	ENSG00000263816
Ensembl biotype	miRNA
Entrez	100846992
RNAcentral	URS000075D7EF — miRNA, 65 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584899

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584899 — 1 exons

Exon	Start	End
ENSE00002711631	132945707	132945771

Expression profiles

Bgee: expression breadth broad, 35 present calls, max score 81.97.

Top tissues by expression

35 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.97	gold quality
calcaneal tendon	UBERON:0003701	81.06	gold quality
monocyte	CL:0000576	80.45	gold quality
lung	UBERON:0002048	79.31	gold quality
heart	UBERON:0000948	76.69	gold quality
right lobe of thyroid gland	UBERON:0001119	75.49	gold quality
blood	UBERON:0000178	75.26	gold quality
lower esophagus muscularis layer	UBERON:0035833	72.00	gold quality
thyroid gland	UBERON:0002046	71.56	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.52	gold quality
tibial artery	UBERON:0007610	68.40	gold quality
esophagus mucosa	UBERON:0002469	67.86	gold quality
fundus of stomach	UBERON:0001160	67.59	gold quality
granulocyte	CL:0000094	67.25	gold quality
adipose tissue	UBERON:0001013	67.17	gold quality
ascending aorta	UBERON:0001496	67.04	gold quality
omental fat pad	UBERON:0010414	67.00	gold quality
testis	UBERON:0000473	66.96	gold quality
zone of skin	UBERON:0000014	66.60	gold quality
left testis	UBERON:0004533	66.48	gold quality
transverse colon	UBERON:0001157	65.68	gold quality
right testis	UBERON:0004534	65.48	gold quality
nucleus accumbens	UBERON:0001882	65.17	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.68	gold quality
skin of leg	UBERON:0001511	64.67	gold quality
skin of abdomen	UBERON:0001416	64.30	gold quality
right frontal lobe	UBERON:0002810	63.74	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.84	gold quality
anterior cingulate cortex	UBERON:0009835	62.47	gold quality
minor salivary gland	UBERON:0001830	60.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.25

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.