MIR548AX

Summary

MIR548AX (microRNA 548ax, HGNC:43528) is a microRNA gene on chromosome Xp22.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847063 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43528
Approved symbol	MIR548AX
Name	microRNA 548ax
Location	Xp22.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548ax
Ensembl gene	ENSG00000263652
Ensembl biotype	miRNA
Entrez	100847063
RNAcentral	URS000075A3DD — ncRNA, 73 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580117

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580117 — 1 exons

Exon	Start	End
ENSE00002704852	11318614	11318686

Expression profiles

Bgee: expression breadth broad, 56 present calls, max score 80.42.

Top tissues by expression

56 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	80.42	gold quality
calcaneal tendon	UBERON:0003701	79.79	gold quality
stomach	UBERON:0000945	78.98	gold quality
endometrium	UBERON:0001295	73.88	gold quality
kidney	UBERON:0002113	72.93	gold quality
lung	UBERON:0002048	72.33	gold quality
adult mammalian kidney	UBERON:0000082	71.93	gold quality
gastrocnemius	UBERON:0001388	71.91	gold quality
monocyte	CL:0000576	70.71	gold quality
blood	UBERON:0000178	70.60	gold quality
heart	UBERON:0000948	69.89	gold quality
body of stomach	UBERON:0001161	69.33	gold quality
right atrium auricular region	UBERON:0006631	68.63	gold quality
esophagus mucosa	UBERON:0002469	68.03	gold quality
intestine	UBERON:0000160	67.41	gold quality
ovary	UBERON:0000992	66.98	gold quality
liver	UBERON:0002107	66.79	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.76	gold quality
fundus of stomach	UBERON:0001160	66.70	gold quality
right lobe of liver	UBERON:0001114	66.12	gold quality
ascending aorta	UBERON:0001496	65.12	gold quality
upper lobe of left lung	UBERON:0008952	65.01	gold quality
left coronary artery	UBERON:0001626	64.83	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.82	gold quality
tibial artery	UBERON:0007610	64.50	gold quality
left ovary	UBERON:0002119	64.29	gold quality
ectocervix	UBERON:0012249	64.14	gold quality
body of pancreas	UBERON:0001150	64.04	gold quality
substantia nigra	UBERON:0002038	63.80	gold quality
colon	UBERON:0001155	63.36	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (25): MIR548AA1 (ENSG00000207704), MIR579 (ENSG00000207956), MIR548P (ENSG00000221263), MIR548K (ENSG00000221333), MIR548F3 (ENSG00000221436), MIR548F1 (ENSG00000221594), MIR548N (ENSG00000221669), MIR548H3 (ENSG00000221698), MIR548AN (ENSG00000263515), MIR548X2 (ENSG00000263581), MIR548AS (ENSG00000263741), MIR548AV (ENSG00000263750), MIR548S (ENSG00000265056), MIR548AQ (ENSG00000265470), MIR548AG2 (ENSG00000265617), MIR548AJ1 (ENSG00000265669), MIR548AG1 (ENSG00000265829), MIR548X (ENSG00000265841), MIR548Z (ENSG00000266016), MIR548H5 (ENSG00000266807), MIR548AE1 (ENSG00000266808), MIR548O2 (ENSG00000275453), MIR548AY (ENSG00000276147), MIR548AZ (ENSG00000276479), MIR548AH (ENSG00000283682)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.