MIR548AY

Summary

MIR548AY (microRNA 548ay, HGNC:49943) is a microRNA gene on chromosome 3p22.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465247 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49943
Approved symbol	MIR548AY
Name	microRNA 548ay
Location	3p22.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548ay
Ensembl gene	ENSG00000276147
Ensembl biotype	miRNA
Entrez	102465247
RNAcentral	URS000075B13F — miRNA, 107 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000617669

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617669 — 1 exons

Exon	Start	End
ENSE00003746412	32506283	32506389

Expression profiles

Bgee: expression breadth broad, 97 present calls, max score 98.20.

Top tissues by expression

97 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	98.20	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	84.28	gold quality
monocyte	CL:0000576	79.38	gold quality
adrenal tissue	UBERON:0018303	79.21	gold quality
calcaneal tendon	UBERON:0003701	77.38	gold quality
blood	UBERON:0000178	76.08	gold quality
duodenum	UBERON:0002114	75.92	gold quality
endometrium	UBERON:0001295	75.77	gold quality
body of pancreas	UBERON:0001150	74.73	gold quality
islet of Langerhans	UBERON:0000006	74.47	gold quality
stomach	UBERON:0000945	74.29	gold quality
muscle of leg	UBERON:0001383	74.24	gold quality
gastrocnemius	UBERON:0001388	74.01	gold quality
right ovary	UBERON:0002118	73.88	gold quality
adult mammalian kidney	UBERON:0000082	73.63	gold quality
bone marrow	UBERON:0002371	73.57	gold quality
body of stomach	UBERON:0001161	73.41	gold quality
right hemisphere of cerebellum	UBERON:0014890	72.66	gold quality
right coronary artery	UBERON:0001625	72.65	gold quality
endocervix	UBERON:0000458	72.55	gold quality
cerebellar hemisphere	UBERON:0002245	72.50	gold quality
metanephros cortex	UBERON:0010533	71.78	gold quality
right adrenal gland	UBERON:0001233	71.75	gold quality
left coronary artery	UBERON:0001626	71.72	gold quality
heart	UBERON:0000948	71.36	gold quality
adrenal gland	UBERON:0002369	71.33	gold quality
left adrenal gland cortex	UBERON:0035825	71.24	gold quality
thoracic aorta	UBERON:0001515	70.97	gold quality
ascending aorta	UBERON:0001496	70.90	gold quality
left adrenal gland	UBERON:0001234	70.75	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (25): MIR548AA1 (ENSG00000207704), MIR579 (ENSG00000207956), MIR548P (ENSG00000221263), MIR548K (ENSG00000221333), MIR548F3 (ENSG00000221436), MIR548F1 (ENSG00000221594), MIR548N (ENSG00000221669), MIR548H3 (ENSG00000221698), MIR548AN (ENSG00000263515), MIR548X2 (ENSG00000263581), MIR548AX (ENSG00000263652), MIR548AS (ENSG00000263741), MIR548AV (ENSG00000263750), MIR548S (ENSG00000265056), MIR548AQ (ENSG00000265470), MIR548AG2 (ENSG00000265617), MIR548AJ1 (ENSG00000265669), MIR548AG1 (ENSG00000265829), MIR548X (ENSG00000265841), MIR548Z (ENSG00000266016), MIR548H5 (ENSG00000266807), MIR548AE1 (ENSG00000266808), MIR548O2 (ENSG00000275453), MIR548AZ (ENSG00000276479), MIR548AH (ENSG00000283682)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.