MIR548B

Summary

MIR548B (microRNA 548b, HGNC:32799) is a microRNA gene on chromosome 6q22.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693128 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32799
Approved symbol	MIR548B
Name	microRNA 548b
Location	6q22.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548b
Ensembl gene	ENSG00000207982
Ensembl biotype	miRNA
Entrez	693128
RNAcentral	URS000075E69F — miRNA, 97 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385247

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385247 — 1 exons

Exon	Start	End
ENSE00001500253	119069047	119069143

Expression profiles

Bgee: expression breadth broad, 73 present calls, max score 80.10.

Top tissues by expression

73 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	80.10	gold quality
duodenum	UBERON:0002114	78.50	gold quality
calcaneal tendon	UBERON:0003701	75.81	gold quality
islet of Langerhans	UBERON:0000006	74.61	gold quality
blood	UBERON:0000178	74.55	gold quality
endometrium	UBERON:0001295	74.43	gold quality
gastrocnemius	UBERON:0001388	74.15	gold quality
stomach	UBERON:0000945	72.62	gold quality
kidney	UBERON:0002113	72.38	gold quality
left coronary artery	UBERON:0001626	72.33	gold quality
endocervix	UBERON:0000458	72.17	gold quality
heart	UBERON:0000948	71.69	gold quality
right coronary artery	UBERON:0001625	69.51	gold quality
ascending aorta	UBERON:0001496	69.35	gold quality
thoracic aorta	UBERON:0001515	69.11	gold quality
body of pancreas	UBERON:0001150	69.08	gold quality
body of stomach	UBERON:0001161	68.92	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.59	gold quality
tibial artery	UBERON:0007610	68.19	gold quality
right atrium auricular region	UBERON:0006631	68.12	gold quality
descending thoracic aorta	UBERON:0002345	68.08	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.89	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.61	gold quality
substantia nigra	UBERON:0002038	67.59	gold quality
corpus callosum	UBERON:0002336	67.46	gold quality
lower esophagus	UBERON:0013473	67.38	gold quality
esophagus mucosa	UBERON:0002469	67.32	gold quality
right ovary	UBERON:0002118	67.24	gold quality
smooth muscle tissue	UBERON:0001135	67.16	gold quality
omental fat pad	UBERON:0010414	66.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.15

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• Report that miR-374a and miR-548b modulation by Axl regulates tumorigenicity and gefitinib resistance in lung cancer. (PMID:24832599)
• This study demonstrated that the miR-548b exerts its tumor-suppressive activity in glioma through repression of MTA2. Restoration of miR-548b may have therapeutic potential in glioma. (PMID:27682888)
• MiR-548b-3p inhibits proliferation and migration of breast cancer cells by targeting MDM2. (PMID:32271428)
• Human Lungs Airway Epithelium Upregulate MicroRNA-17 and MicroRNA-548b in Response to Cold Ischemia and Ex Vivo Reperfusion. (PMID:32590607)
• MiR-548b suppresses proliferative capacity of colorectal cancer by binding WNT2. (PMID:33155209)
• miR-548b Suppresses Melanoma Cell Growth, Migration, and Invasion by Negatively Regulating Its Target Gene HMGB1. (PMID:33750228)
• A novel regQTL-SNP and the risk of lung cancer: a multi-dimensional study. (PMID:34596730)
• Small non-coding RNA profiling in breast cancer: plasma U6 snRNA, miR-451a and miR-548b-5p as novel diagnostic and prognostic biomarkers. (PMID:34993725)
• Mechanism of miR-548b-5p down-regulating FZD7 to impede the migratory and invasive behavior of gastric carcinoma cells. (PMID:38279460)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.