MIR548BA

Summary

MIR548BA (microRNA 548ba, HGNC:50260) is a microRNA gene on chromosome 2p16.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102465854 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50260
Approved symbol	MIR548BA
Name	microRNA 548ba
Location	2p16.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548ba
Ensembl gene	ENSG00000212036
Ensembl biotype	miRNA
Entrez	102465854
RNAcentral	URS000075CC0C — miRNA, 56 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390747

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390747 — 1 exons

Exon	Start	End
ENSE00001508424	49059603	49059658

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 79.40.

Top tissues by expression

4 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right frontal lobe	UBERON:0002810	79.40	gold quality
left ovary	UBERON:0002119	70.58	gold quality
left lobe of thyroid gland	UBERON:0001120	63.85	gold quality
left testis	UBERON:0004533	42.73	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Target prediction and validation of microRNAs expressed from FSHR and aromatase genes in human ovarian granulosa cells. (PMID:32042028)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.