MIR548C

Summary

MIR548C (microRNA 548c, HGNC:32800) is a microRNA gene on chromosome 12q14.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693129 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32800
Approved symbol	MIR548C
Name	microRNA 548c
Location	12q14.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548c
Ensembl gene	ENSG00000207546
Ensembl biotype	miRNA
Entrez	693129
RNAcentral	URS000075DBE5 — ncRNA, 97 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384815

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384815 — 1 exons

Exon	Start	End
ENSE00001808994	64622509	64622605

Expression profiles

Bgee: expression breadth ubiquitous, 107 present calls, max score 89.59.

Top tissues by expression

107 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	89.59	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.38	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	80.32	gold quality
calcaneal tendon	UBERON:0003701	79.81	gold quality
vermiform appendix	UBERON:0001154	78.45	gold quality
monocyte	CL:0000576	78.04	gold quality
leukocyte	CL:0000738	77.54	gold quality
corpus callosum	UBERON:0002336	77.35	gold quality
blood	UBERON:0000178	76.35	gold quality
endometrium	UBERON:0001295	74.38	gold quality
prefrontal cortex	UBERON:0000451	74.37	gold quality
granulocyte	CL:0000094	71.54	gold quality
placenta	UBERON:0001987	70.45	gold quality
muscle of leg	UBERON:0001383	70.12	gold quality
kidney	UBERON:0002113	69.30	gold quality
liver	UBERON:0002107	69.28	gold quality
gastrocnemius	UBERON:0001388	69.24	gold quality
rectum	UBERON:0001052	68.86	gold quality
cerebellar hemisphere	UBERON:0002245	68.74	gold quality
right hemisphere of cerebellum	UBERON:0014890	68.40	gold quality
stomach	UBERON:0000945	68.37	gold quality
lymph node	UBERON:0000029	67.91	gold quality
islet of Langerhans	UBERON:0000006	67.80	gold quality
fundus of stomach	UBERON:0001160	67.47	gold quality
left ovary	UBERON:0002119	67.30	gold quality
ovary	UBERON:0000992	67.18	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.40	gold quality
bone marrow	UBERON:0002371	66.15	gold quality
adult mammalian kidney	UBERON:0000082	66.06	gold quality
heart	UBERON:0000948	65.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 23)

• The studies suggest that miRNA-548 family signature in PBMCs can therefore be used to detect early heart failure. (PMID:23735785)
• Low miR-548 expression is associated with chronic rejection in Bronchiolitis Obliterans Syndrome patients following lung transplantation. (PMID:25649290)
• Data support the idea that one of the consequences of doxorubicin treatment is the generation of resistance to therapy, and reveal the implication of miR-548c-3p in MCF-7 cell viability after doxorubicin treatment. (PMID:25802200)
• This study shows that hsa-miR548-l regulates FOXC1 translation, contributing to better understand the fine regulation of the biological function of this transcription factor. (PMID:25809640)
• In situ BRCA1-related expression parameters could be used for clinical purposes at the time of diagnosis. In contrast, miR-548c-5p showed a promising potential as a prognostic factor in Triple negative breast cancers . (PMID:26490435)
• Findings suggest that miR-548c directly downregulates Twist, and provide a novel mechanism for Twist upregulation in both endometrial and ovarian cancers. (PMID:26762267)
• miR-548j functions as a metastasis-promoting miRNA to regulate breast cancer cell invasion and metastasis by targeting Tensin1 and activating Cdc42. (PMID:26949125)
• novel HLA-G-regulating miRs, miR-628-5p and miR-548q, were identified in renal cell carcinoma (PMID:27057628)
• It has been shown that the expression of miR-29a as well as miR-548a was positively correlated with tumor stage and lymph node metastasis, whereas the expression of miR-4768-3p was negatively correlated with lymph node metastasis. (PMID:28430523)
• Critical roles of miR-548k-lncRNA-LET regulation axis in esophageal squamous cell carcinoma (ESCC); the miR-548k-lncRNA-LET regulation axis may be promising prognostic biomarkers and therapeutic targets for ESCC. (PMID:29126868)
• PTPRO was significantly upregulated and negatively associated with miR-548c-5p in placental mononuclear cells in patients with preeclampsia. (PMID:30443949)
• The present study demonstrated that three miRNAs (miR-548q, miR-630 and miR940) might be novel and useful biomarkers for nasopharyngeal carcinoma (NPC) detection. A two-miRNA signature (miR-548q and miR940) may be considered as a better biomarker for NPC detection with relatively high sensitivity and specificity. (PMID:30475754)
• MiR-548b-3p regulates proliferation, apoptosis and mitochondrial function by targeting CIP2A in HCC. (PMID:30671469)
• miR-548c-5p may serve as a cancer suppressor in colorectal cancer by targeting PGK1. (PMID:30932211)
• MiR-548c-3p suppressed the progression of papillary thyroid carcinoma via inhibition of the HIF1alpha-mediated VEGF signaling pathway. (PMID:31378898)
• The expression pattern of FOXC2 during podocyte differentiation seems to be affected by miR-548c-5p. (PMID:31531679)
• miR-548x and miR-4698 controlled cell proliferation by affecting the PI3K/AKT signaling pathway in Glioblastoma cell lines. (PMID:32005873)
• MicroRNA-548c-5p inhibits the proliferation of breast cancer cells through regulating Wnt/beta-catenin signaling pathway. (PMID:32329856)
• Silencing of hsa_circ_0101145 reverses the epithelial-mesenchymal transition in hepatocellular carcinoma via regulation of the miR-548c-3p/LAMC2 axis. (PMID:32554866)
• LINC00266-1/miR-548c-3p/SMAD2 feedback loop stimulates the development of osteosarcoma. (PMID:32709857)
• Effects of miR-432 and miR-548c-3p on the proliferation and invasion of osteosarcoma cells. (PMID:32862605)
• cFUT8 promotes liver cancer progression by miR-548c/FUT8 axis. (PMID:33500381)
• miR-548c-3p targets TRIM22 to attenuate the Peg-IFN-alpha therapeutic efficacy in HBeAg-positive patients with chronic hepatitis B. (PMID:37019306)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.