MIR548D1

Summary

MIR548D1 (microRNA 548d-1, HGNC:32801) is a microRNA gene on chromosome 8q24.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693130 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32801
Approved symbol	MIR548D1
Name	microRNA 548d-1
Location	8q24.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548d-1
Ensembl gene	ENSG00000283172
Ensembl biotype	miRNA
Entrez	693130
RNAcentral	URS000075B920 — miRNA, 97 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636914

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636914 — 1 exons

Exon	Start	End
ENSE00003792174	123348034	123348130

Expression profiles

Bgee: expression breadth ubiquitous, 102 present calls, max score 88.30.

Top tissues by expression

102 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	88.30	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	80.94	gold quality
endometrium	UBERON:0001295	78.55	gold quality
adrenal tissue	UBERON:0018303	74.37	gold quality
monocyte	CL:0000576	74.04	gold quality
duodenum	UBERON:0002114	72.39	gold quality
kidney	UBERON:0002113	71.61	gold quality
rectum	UBERON:0001052	71.09	gold quality
liver	UBERON:0002107	70.92	gold quality
vermiform appendix	UBERON:0001154	70.41	gold quality
lymph node	UBERON:0000029	70.39	gold quality
blood	UBERON:0000178	70.14	gold quality
gastrocnemius	UBERON:0001388	69.93	gold quality
muscle of leg	UBERON:0001383	69.91	gold quality
islet of Langerhans	UBERON:0000006	68.96	gold quality
placenta	UBERON:0001987	68.96	gold quality
stomach	UBERON:0000945	68.86	gold quality
right coronary artery	UBERON:0001625	67.52	gold quality
descending thoracic aorta	UBERON:0002345	67.38	gold quality
calcaneal tendon	UBERON:0003701	67.38	gold quality
right lobe of liver	UBERON:0001114	67.18	gold quality
body of stomach	UBERON:0001161	66.83	gold quality
heart	UBERON:0000948	66.71	gold quality
body of pancreas	UBERON:0001150	66.66	gold quality
right adrenal gland	UBERON:0001233	66.61	gold quality
heart left ventricle	UBERON:0002084	66.14	gold quality
right adrenal gland cortex	UBERON:0035827	66.06	gold quality
smooth muscle tissue	UBERON:0001135	65.77	gold quality
right lung	UBERON:0002167	65.77	gold quality
thoracic aorta	UBERON:0001515	65.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• these results validate the role of miR-548d-3p and miR-559 in regulating the ERBB2 expression. (PMID:19486885)
• MicroRNA miR-548d was identified as a potential superior regulator for the development and progression of pancreatic cancer by targeting multiple factors of crucial pathways. (PMID:21946813)
• By directly targeting and downregulating PPARgamma, miR-548d-5p suppresses the dexamethasone-induced adipogenic differentiation of hBMSCs and enhances their osteogenic potential (PMID:24929254)
• miR548d-3p inhibits the growth and migration of osteosarcoma tumor cells MG63 and U2-OS by downregulating KRAS (PMID:31327761)
• miR-548d-3p Alters Parasite Growth and Inflammation in Leishmania (Viannia) braziliensis Infection. (PMID:34178725)
• Downregulation of hsa-miR-548d-3p and overexpression of HOXA9 in diffuse large B-cell lymphoma patients and the risk of R-CHOP chemotherapy resistance and disease progression. (PMID:35830966)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.