MIR548D2

Summary

MIR548D2 (microRNA 548d-2, HGNC:32802) is a microRNA gene on chromosome 17q24.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693131 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32802
Approved symbol	MIR548D2
Name	microRNA 548d-2
Location	17q24.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548d-2
Ensembl gene	ENSG00000263690
Ensembl biotype	miRNA
Entrez	693131
RNAcentral	URS0000759C79 — miRNA, 97 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582790

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582790 — 1 exons

Exon	Start	End
ENSE00002704258	67471489	67471585

Expression profiles

Bgee: expression breadth ubiquitous, 105 present calls, max score 83.59.

Top tissues by expression

105 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	83.59	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.55	gold quality
calcaneal tendon	UBERON:0003701	78.47	gold quality
blood	UBERON:0000178	75.87	gold quality
granulocyte	CL:0000094	75.46	gold quality
monocyte	CL:0000576	74.29	gold quality
sural nerve	UBERON:0015488	73.24	gold quality
skeletal muscle tissue	UBERON:0001134	72.80	gold quality
endometrium	UBERON:0001295	72.55	gold quality
liver	UBERON:0002107	71.97	gold quality
lymph node	UBERON:0000029	70.57	gold quality
putamen	UBERON:0001874	69.76	gold quality
right lobe of liver	UBERON:0001114	69.51	gold quality
adult mammalian kidney	UBERON:0000082	69.26	gold quality
muscle of leg	UBERON:0001383	69.22	gold quality
stomach	UBERON:0000945	68.83	gold quality
islet of Langerhans	UBERON:0000006	68.81	gold quality
ectocervix	UBERON:0012249	68.70	gold quality
lower esophagus mucosa	UBERON:0035834	68.58	gold quality
hypothalamus	UBERON:0001898	68.53	gold quality
nucleus accumbens	UBERON:0001882	68.42	gold quality
anterior cingulate cortex	UBERON:0009835	68.23	gold quality
gall bladder	UBERON:0002110	68.02	gold quality
gastrocnemius	UBERON:0001388	68.01	gold quality
caudate nucleus	UBERON:0001873	68.00	gold quality
amygdala	UBERON:0001876	67.82	gold quality
kidney	UBERON:0002113	67.67	gold quality
corpus callosum	UBERON:0002336	67.15	gold quality
body of stomach	UBERON:0001161	66.94	gold quality
substantia nigra	UBERON:0002038	66.94	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• these results validate the role of miR-548d-3p and miR-559 in regulating the ERBB2 expression. (PMID:19486885)
• MicroRNA miR-548d was identified as a potential superior regulator for the development and progression of pancreatic cancer by targeting multiple factors of crucial pathways. (PMID:21946813)
• By directly targeting and downregulating PPARgamma, miR-548d-5p suppresses the dexamethasone-induced adipogenic differentiation of hBMSCs and enhances their osteogenic potential (PMID:24929254)
• miR548d-3p inhibits the growth and migration of osteosarcoma tumor cells MG63 and U2-OS by downregulating KRAS (PMID:31327761)
• miR-548d-3p Alters Parasite Growth and Inflammation in Leishmania (Viannia) braziliensis Infection. (PMID:34178725)
• miR-548d-3p Is Up-Regulated in Human Visceral Leishmaniasis and Suppresses Parasite Growth in Macrophages. (PMID:35265535)
• Downregulation of hsa-miR-548d-3p and overexpression of HOXA9 in diffuse large B-cell lymphoma patients and the risk of R-CHOP chemotherapy resistance and disease progression. (PMID:35830966)
• LncRNA TPTEP1 inhibits the migration and invasion of gastric cancer cells through miR-548d-3p/KLF9/PER1 axis. (PMID:35985238)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.