MIR548E

Summary

MIR548E (microRNA 548e, HGNC:35275) is a microRNA gene on chromosome 10q25.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313921 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35275
Approved symbol	MIR548E
Name	microRNA 548e
Location	10q25.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548e
Ensembl gene	ENSG00000221214
Ensembl biotype	miRNA
Entrez	100313921
RNAcentral	URS0000759FC7 — miRNA, 88 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408287

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408287 — 1 exons

Exon	Start	End
ENSE00001564922	110988926	110989013

Expression profiles

Bgee: expression breadth broad, 71 present calls, max score 91.11.

Top tissues by expression

71 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	91.11	gold quality
adult mammalian kidney	UBERON:0000082	85.86	gold quality
bone marrow	UBERON:0002371	85.59	gold quality
calcaneal tendon	UBERON:0003701	83.78	gold quality
blood	UBERON:0000178	83.51	gold quality
liver	UBERON:0002107	81.98	gold quality
duodenum	UBERON:0002114	80.83	gold quality
adrenal tissue	UBERON:0018303	80.61	gold quality
stomach	UBERON:0000945	78.14	gold quality
endometrium	UBERON:0001295	77.91	gold quality
monocyte	CL:0000576	76.79	gold quality
heart	UBERON:0000948	73.78	gold quality
Ammon’s horn	UBERON:0001954	72.80	gold quality
islet of Langerhans	UBERON:0000006	72.65	gold quality
intestine	UBERON:0000160	71.39	gold quality
gastrocnemius	UBERON:0001388	70.99	gold quality
lung	UBERON:0002048	70.93	gold quality
caudate nucleus	UBERON:0001873	70.63	gold quality
urinary bladder	UBERON:0001255	70.09	gold quality
gall bladder	UBERON:0002110	69.79	gold quality
body of stomach	UBERON:0001161	69.50	gold quality
colon	UBERON:0001155	69.09	gold quality
ascending aorta	UBERON:0001496	69.07	gold quality
substantia nigra	UBERON:0002038	69.07	gold quality
corpus callosum	UBERON:0002336	69.07	gold quality
body of pancreas	UBERON:0001150	68.83	gold quality
thoracic aorta	UBERON:0001515	68.53	gold quality
smooth muscle tissue	UBERON:0001135	68.38	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.27	gold quality
left coronary artery	UBERON:0001626	68.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.77

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Collectively, the data show that exosomal miR-146a-5p and miR-548e-5p from amniotic fluid-derived mesenchymal stem cells have anti-inflammatory effects on human trophoblast cells and may be novel targets for treating inflammatory diseases and associated problems that occur during pregnancy, such as preterm birth. (PMID:31588496)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.