MIR548F1

Summary

MIR548F1 (microRNA 548f-1, HGNC:35305) is a microRNA gene on chromosome 10q21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302192 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35305
Approved symbol	MIR548F1
Name	microRNA 548f-1
Location	10q21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548f-1
Ensembl gene	ENSG00000221594
Ensembl biotype	miRNA
Entrez	100302192
RNAcentral	URS000075A845 — ncRNA, 84 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408667

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408667 — 1 exons

Exon	Start	End
ENSE00001809306	54607874	54607957

Expression profiles

Bgee: expression breadth broad, 19 present calls, max score 82.05.

Top tissues by expression

19 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart	UBERON:0000948	82.05	gold quality
kidney	UBERON:0002113	77.33	gold quality
adult mammalian kidney	UBERON:0000082	70.31	gold quality
blood	UBERON:0000178	69.33	gold quality
esophagus mucosa	UBERON:0002469	66.90	gold quality
body of stomach	UBERON:0001161	65.75	gold quality
transverse colon	UBERON:0001157	65.49	gold quality
anterior cingulate cortex	UBERON:0009835	64.82	gold quality
vagina	UBERON:0000996	63.56	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.55	gold quality
caudate nucleus	UBERON:0001873	63.35	gold quality
subcutaneous adipose tissue	UBERON:0002190	61.08	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	59.96	gold quality
skin of leg	UBERON:0001511	59.93	gold quality
right frontal lobe	UBERON:0002810	54.88	gold quality
thyroid gland	UBERON:0002046	54.04	gold quality
tibial nerve	UBERON:0001323	52.29	gold quality
left testis	UBERON:0004533	48.25	gold quality
corpus callosum	UBERON:0002336	43.52	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (25): MIR548AA1 (ENSG00000207704), MIR579 (ENSG00000207956), MIR548P (ENSG00000221263), MIR548K (ENSG00000221333), MIR548F3 (ENSG00000221436), MIR548N (ENSG00000221669), MIR548H3 (ENSG00000221698), MIR548AN (ENSG00000263515), MIR548X2 (ENSG00000263581), MIR548AX (ENSG00000263652), MIR548AS (ENSG00000263741), MIR548AV (ENSG00000263750), MIR548S (ENSG00000265056), MIR548AQ (ENSG00000265470), MIR548AG2 (ENSG00000265617), MIR548AJ1 (ENSG00000265669), MIR548AG1 (ENSG00000265829), MIR548X (ENSG00000265841), MIR548Z (ENSG00000266016), MIR548H5 (ENSG00000266807), MIR548AE1 (ENSG00000266808), MIR548O2 (ENSG00000275453), MIR548AY (ENSG00000276147), MIR548AZ (ENSG00000276479), MIR548AH (ENSG00000283682)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.