MIR548F2

Summary

MIR548F2 (microRNA 548f-2, HGNC:35306) is a microRNA gene on chromosome 2q34.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313771 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35306
Approved symbol	MIR548F2
Name	microRNA 548f-2
Location	2q34
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548f-2
Ensembl gene	ENSG00000221782
Ensembl biotype	miRNA
Entrez	100313771
RNAcentral	URS000075E8A1 — miRNA, 98 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408855

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408855 — 1 exons

Exon	Start	End
ENSE00001565490	212426263	212426360

Expression profiles

Bgee: expression breadth broad, 95 present calls, max score 96.98.

Top tissues by expression

95 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	96.98	gold quality
corpus callosum	UBERON:0002336	94.01	gold quality
adrenal tissue	UBERON:0018303	85.54	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	82.29	gold quality
calcaneal tendon	UBERON:0003701	81.74	gold quality
liver	UBERON:0002107	81.01	gold quality
lower esophagus mucosa	UBERON:0035834	78.57	gold quality
sural nerve	UBERON:0015488	78.55	gold quality
right lobe of liver	UBERON:0001114	78.43	gold quality
monocyte	CL:0000576	78.34	gold quality
prefrontal cortex	UBERON:0000451	78.01	gold quality
blood	UBERON:0000178	77.52	gold quality
bone marrow	UBERON:0002371	77.25	gold quality
kidney	UBERON:0002113	77.04	gold quality
endometrium	UBERON:0001295	76.19	gold quality
muscle of leg	UBERON:0001383	75.95	gold quality
heart	UBERON:0000948	75.61	gold quality
adrenal gland	UBERON:0002369	75.51	gold quality
stomach	UBERON:0000945	74.77	gold quality
islet of Langerhans	UBERON:0000006	73.97	gold quality
gastrocnemius	UBERON:0001388	73.91	gold quality
adult mammalian kidney	UBERON:0000082	72.59	gold quality
body of pancreas	UBERON:0001150	72.46	gold quality
body of stomach	UBERON:0001161	71.12	gold quality
skin of abdomen	UBERON:0001416	70.89	gold quality
lung	UBERON:0002048	70.74	gold quality
Ammon’s horn	UBERON:0001954	70.69	gold quality
tibial artery	UBERON:0007610	70.54	gold quality
popliteal artery	UBERON:0002250	70.49	gold quality
muscle layer of sigmoid colon	UBERON:0035805	70.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.22

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.