MIR548F3

Summary

MIR548F3 (microRNA 548f-3, HGNC:35307) is a microRNA gene on chromosome 5q22.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302159 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35307
Approved symbol	MIR548F3
Name	microRNA 548f-3
Location	5q22.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-548f-3
Ensembl gene	ENSG00000221436
Ensembl biotype	miRNA
Entrez	100302159
RNAcentral	URS000075B2BD — miRNA, 87 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408509

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408509 — 1 exons

Exon	Start	End
ENSE00001565144	110513829	110513915

Expression profiles

Bgee: expression breadth broad, 56 present calls, max score 80.11.

Top tissues by expression

56 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endometrium	UBERON:0001295	80.11	gold quality
blood	UBERON:0000178	75.27	gold quality
body of pancreas	UBERON:0001150	73.91	gold quality
adrenal tissue	UBERON:0018303	73.64	gold quality
skin of leg	UBERON:0001511	72.94	gold quality
heart	UBERON:0000948	72.17	gold quality
ascending aorta	UBERON:0001496	71.77	gold quality
adult mammalian kidney	UBERON:0000082	71.43	gold quality
caudate nucleus	UBERON:0001873	70.52	gold quality
right atrium auricular region	UBERON:0006631	70.38	gold quality
kidney	UBERON:0002113	68.80	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.62	gold quality
stomach	UBERON:0000945	68.60	gold quality
tibial artery	UBERON:0007610	68.60	gold quality
Ammon’s horn	UBERON:0001954	68.59	gold quality
left adrenal gland cortex	UBERON:0035825	67.37	gold quality
hypothalamus	UBERON:0001898	67.22	gold quality
omental fat pad	UBERON:0010414	67.00	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.71	gold quality
descending thoracic aorta	UBERON:0002345	66.59	gold quality
small intestine Peyer’s patch	UBERON:0003454	66.16	gold quality
body of stomach	UBERON:0001161	66.12	gold quality
vagina	UBERON:0000996	65.61	gold quality
thoracic mammary gland	UBERON:0005200	64.73	gold quality
left ovary	UBERON:0002119	64.70	gold quality
putamen	UBERON:0001874	64.14	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.03	gold quality
minor salivary gland	UBERON:0001830	63.82	gold quality
anterior cingulate cortex	UBERON:0009835	63.79	gold quality
body of uterus	UBERON:0009853	63.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (25): MIR548AA1 (ENSG00000207704), MIR579 (ENSG00000207956), MIR548P (ENSG00000221263), MIR548K (ENSG00000221333), MIR548F1 (ENSG00000221594), MIR548N (ENSG00000221669), MIR548H3 (ENSG00000221698), MIR548AN (ENSG00000263515), MIR548X2 (ENSG00000263581), MIR548AX (ENSG00000263652), MIR548AS (ENSG00000263741), MIR548AV (ENSG00000263750), MIR548S (ENSG00000265056), MIR548AQ (ENSG00000265470), MIR548AG2 (ENSG00000265617), MIR548AJ1 (ENSG00000265669), MIR548AG1 (ENSG00000265829), MIR548X (ENSG00000265841), MIR548Z (ENSG00000266016), MIR548H5 (ENSG00000266807), MIR548AE1 (ENSG00000266808), MIR548O2 (ENSG00000275453), MIR548AY (ENSG00000276147), MIR548AZ (ENSG00000276479), MIR548AH (ENSG00000283682)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.